Stochastic simulation of prokaryotic two-component signalling indicates stochasticity-induced active-state locking and growth-rate dependent bistability

Signal transduction by prokaryotes almost exclusively relies on two-component systems for sensing and responding to (extracellular) signals. Here, we use stochastic models of two-component systems to better understand the impact of stochasticity on the fidelity and robustness of signal transmission,...

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Veröffentlicht in:	Molecular bioSystems 2014-01, Vol.10 (9), p.2338-2346
Hauptverfasser:	Wei, Katy, Moinat, Maxim, Maarleveld, Timo R, Bruggeman, Frank J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Cell Cycle - physiology Cell Proliferation - physiology Environment Gene Expression - physiology Models, Statistical Prokaryotic Cells - metabolism Prokaryotic Cells - physiology Proteins - metabolism Signal Transduction - physiology Stochastic Processes
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