Application of Positron Emission Tomography in the Detection of Myocardial Metabolism in Pig Ventricular Fibrillation and Asphyxiation Cardiac Arrest Models after Resuscitation
Objective To study the application of positron emission tomography （PET） in detection of myocardia metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Methods Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac...
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| Veröffentlicht in: | Biomedical and environmental sciences 2014-07, Vol.27 (7), p.531-536 |
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| description | Objective To study the application of positron emission tomography （PET） in detection of myocardia metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Methods Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac arrest （VFCA） group （n=16） and an asphyxiation cardiac arrest （ACA） group （n=16）. Cardiac arrest （CA） was induced by programmed electric stimulation or endotracheal tube clamping followed by cardiopulmonary resuscitation （CPR） and defibrillation. At four hours and 24 h after spontaneous circulation was achieved, myocardial metabolism was assessed by PET. 18F-FDG myocardial uptake in PET was analyzed and the maximum standardized uptake value （SUVmax） was measured. Results Spontaneous circulation was 200% and 62.5% in VFCA group and ACA group, respectively. PET demonstrated that the myocardial metabolism injuries was more severe and widespread after ACA than after VFCA. The SUVrnax was higher in VFCA group than in ACA group （P〈0.01）. In VFCA group, SUVmax at 24 h after spontaneous circulation increased to the level of baseline. Conclusion ACA causes more severe cardiac metabol associated with less successful resuscitation. Myocardial sm injuries than VFCA. Myocardial dysfunction is stunning does occur with VFCA but not with ACA. |
| doi_str_mv | 10.3967/bes2014.083 |
| format | Article |
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Methods Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac arrest （VFCA） group （n=16） and an asphyxiation cardiac arrest （ACA） group （n=16）. Cardiac arrest （CA） was induced by programmed electric stimulation or endotracheal tube clamping followed by cardiopulmonary resuscitation （CPR） and defibrillation. At four hours and 24 h after spontaneous circulation was achieved, myocardial metabolism was assessed by PET. 18F-FDG myocardial uptake in PET was analyzed and the maximum standardized uptake value （SUVmax） was measured. Results Spontaneous circulation was 200% and 62.5% in VFCA group and ACA group, respectively. PET demonstrated that the myocardial metabolism injuries was more severe and widespread after ACA than after VFCA. The SUVrnax was higher in VFCA group than in ACA group （P〈0.01）. In VFCA group, SUVmax at 24 h after spontaneous circulation increased to the level of baseline. Conclusion ACA causes more severe cardiac metabol associated with less successful resuscitation. Myocardial sm injuries than VFCA. Myocardial dysfunction is stunning does occur with VFCA but not with ACA.</description><identifier>ISSN: 0895-3988</identifier><identifier>EISSN: 2214-0190</identifier><identifier>DOI: 10.3967/bes2014.083</identifier><identifier>PMID: 25073912</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Asphyxia ; Asphyxia - physiopathology ; Cardiac arrest ; Cardiopulmonary Resuscitation ; Gene Expression Regulation ; Heart Arrest - etiology ; Heart Arrest - metabolism ; Heart Arrest - therapy ; Myocardium - metabolism ; Positron emission tomography ; Positron-Emission Tomography - methods ; Random Allocation ; Spontaneous circulation ; Standardized uptake value ; Survival time ; Swine ; Ventricular fibrillation ; Ventricular Fibrillation - metabolism ; 代谢 ; 小型猪 ; 心室 ; 心肌损伤 ; 心脏 ; 正电子发射断层扫描 ; 窒息 ; 颤动</subject><ispartof>Biomedical and environmental sciences, 2014-07, Vol.27 (7), p.531-536</ispartof><rights>2014 The Editorial Board of Biomedical and Environmental Sciences</rights><rights>Copyright © 2014 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84046X/84046X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3967/bes2014.083$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25073912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WU, Cai Jun</creatorcontrib><creatorcontrib>LI, Chun Sheng</creatorcontrib><creatorcontrib>ZHANG, Yi</creatorcontrib><creatorcontrib>YANG, Jun</creatorcontrib><title>Application of Positron Emission Tomography in the Detection of Myocardial Metabolism in Pig Ventricular Fibrillation and Asphyxiation Cardiac Arrest Models after Resuscitation</title><title>Biomedical and environmental sciences</title><addtitle>Biomedical and Environmental Sciences</addtitle><description>Objective To study the application of positron emission tomography （PET） in detection of myocardia metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Methods Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac arrest （VFCA） group （n=16） and an asphyxiation cardiac arrest （ACA） group （n=16）. Cardiac arrest （CA） was induced by programmed electric stimulation or endotracheal tube clamping followed by cardiopulmonary resuscitation （CPR） and defibrillation. At four hours and 24 h after spontaneous circulation was achieved, myocardial metabolism was assessed by PET. 18F-FDG myocardial uptake in PET was analyzed and the maximum standardized uptake value （SUVmax） was measured. Results Spontaneous circulation was 200% and 62.5% in VFCA group and ACA group, respectively. PET demonstrated that the myocardial metabolism injuries was more severe and widespread after ACA than after VFCA. The SUVrnax was higher in VFCA group than in ACA group （P〈0.01）. In VFCA group, SUVmax at 24 h after spontaneous circulation increased to the level of baseline. Conclusion ACA causes more severe cardiac metabol associated with less successful resuscitation. Myocardial sm injuries than VFCA. Myocardial dysfunction is stunning does occur with VFCA but not with ACA.</description><subject>Animals</subject><subject>Asphyxia</subject><subject>Asphyxia - physiopathology</subject><subject>Cardiac arrest</subject><subject>Cardiopulmonary Resuscitation</subject><subject>Gene Expression Regulation</subject><subject>Heart Arrest - etiology</subject><subject>Heart Arrest - metabolism</subject><subject>Heart Arrest - therapy</subject><subject>Myocardium - metabolism</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Random Allocation</subject><subject>Spontaneous circulation</subject><subject>Standardized uptake value</subject><subject>Survival time</subject><subject>Swine</subject><subject>Ventricular fibrillation</subject><subject>Ventricular Fibrillation - metabolism</subject><subject>代谢</subject><subject>小型猪</subject><subject>心室</subject><subject>心肌损伤</subject><subject>心脏</subject><subject>正电子发射断层扫描</subject><subject>窒息</subject><subject>颤动</subject><issn>0895-3988</issn><issn>2214-0190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1u1DAUhS1ERYeWFXtksWKT4ps_O8vR0AJSR62qwtaynZsZoyRObQcxb8Uj4mmmrGxdfefY51xC3gO7Kpqaf9YYcgblFRPFK7LKcygzBg17TVZMNFVWNEKck7ch_GKshKYUb8h5XjFeNJCvyN_1NPXWqGjdSF1H712w0af79WBDOA4f3eB2Xk37A7UjjXukXzCieRFsD84o31rV0y1GpV1vw3Ak7-2O_sQxemvmXnl6Y7W3fb-8pMaWrkPy_GOXwebZw9C19xgi3boW-0BVF9HTBwxzMDY-k5fkrFN9wHen84L8uLl-3HzLbu--ft-sbzOTizJmKDg0LShdsrrKU_Au71qsuShMVTGDoEWnKjDAIHUhiloAN2WnDXAOQuvignxafCfvnub0J5kKMZgCjOjmICHZMF5XvEzohxM66wFbOXk7KH-QLy0noFqAlAl_W_QyxcHRYGt9alK2zkpg8rhNedqmTNtMuo-LzuzduHuy4-6_d10Db6CqofgHZKCfQA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>WU, Cai Jun</creator><creator>LI, Chun Sheng</creator><creator>ZHANG, Yi</creator><creator>YANG, Jun</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Application of Positron Emission Tomography in the Detection of Myocardial Metabolism in Pig Ventricular Fibrillation and Asphyxiation Cardiac Arrest Models after Resuscitation</title><author>WU, Cai Jun ; LI, Chun Sheng ; ZHANG, Yi ; YANG, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-e8719d1ab40652041f2fde6783c550ce1b8fa51c101507836817c4fbc17718bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Asphyxia</topic><topic>Asphyxia - physiopathology</topic><topic>Cardiac arrest</topic><topic>Cardiopulmonary Resuscitation</topic><topic>Gene Expression Regulation</topic><topic>Heart Arrest - etiology</topic><topic>Heart Arrest - metabolism</topic><topic>Heart Arrest - therapy</topic><topic>Myocardium - metabolism</topic><topic>Positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Random Allocation</topic><topic>Spontaneous circulation</topic><topic>Standardized uptake value</topic><topic>Survival time</topic><topic>Swine</topic><topic>Ventricular fibrillation</topic><topic>Ventricular Fibrillation - metabolism</topic><topic>代谢</topic><topic>小型猪</topic><topic>心室</topic><topic>心肌损伤</topic><topic>心脏</topic><topic>正电子发射断层扫描</topic><topic>窒息</topic><topic>颤动</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WU, Cai Jun</creatorcontrib><creatorcontrib>LI, Chun Sheng</creatorcontrib><creatorcontrib>ZHANG, Yi</creatorcontrib><creatorcontrib>YANG, Jun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WU, Cai Jun</au><au>LI, Chun Sheng</au><au>ZHANG, Yi</au><au>YANG, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of Positron Emission Tomography in the Detection of Myocardial Metabolism in Pig Ventricular Fibrillation and Asphyxiation Cardiac Arrest Models after Resuscitation</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomedical and Environmental Sciences</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>27</volume><issue>7</issue><spage>531</spage><epage>536</epage><pages>531-536</pages><issn>0895-3988</issn><eissn>2214-0190</eissn><abstract>Objective To study the application of positron emission tomography （PET） in detection of myocardia metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Methods Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac arrest （VFCA） group （n=16） and an asphyxiation cardiac arrest （ACA） group （n=16）. Cardiac arrest （CA） was induced by programmed electric stimulation or endotracheal tube clamping followed by cardiopulmonary resuscitation （CPR） and defibrillation. At four hours and 24 h after spontaneous circulation was achieved, myocardial metabolism was assessed by PET. 18F-FDG myocardial uptake in PET was analyzed and the maximum standardized uptake value （SUVmax） was measured. Results Spontaneous circulation was 200% and 62.5% in VFCA group and ACA group, respectively. PET demonstrated that the myocardial metabolism injuries was more severe and widespread after ACA than after VFCA. The SUVrnax was higher in VFCA group than in ACA group （P〈0.01）. In VFCA group, SUVmax at 24 h after spontaneous circulation increased to the level of baseline. Conclusion ACA causes more severe cardiac metabol associated with less successful resuscitation. Myocardial sm injuries than VFCA. Myocardial dysfunction is stunning does occur with VFCA but not with ACA.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25073912</pmid><doi>10.3967/bes2014.083</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Asphyxia Asphyxia - physiopathology Cardiac arrest Cardiopulmonary Resuscitation Gene Expression Regulation Heart Arrest - etiology Heart Arrest - metabolism Heart Arrest - therapy Myocardium - metabolism Positron emission tomography Positron-Emission Tomography - methods Random Allocation Spontaneous circulation Standardized uptake value Survival time Swine Ventricular fibrillation Ventricular Fibrillation - metabolism 代谢 小型猪 心室 心肌损伤 心脏 正电子发射断层扫描 窒息 颤动 |
| title | Application of Positron Emission Tomography in the Detection of Myocardial Metabolism in Pig Ventricular Fibrillation and Asphyxiation Cardiac Arrest Models after Resuscitation |
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