Macrophage Migration Inhibitory Factor Inhibits the Antiinflammatory Effects of Glucocorticoids via Glucocorticoid‐Induced Leucine Zipper

Objective Glucocorticoids remain a mainstay in the treatment of rheumatoid arthritis (RA). Dose‐dependent adverse effects highlight the need for therapies that regulate glucocorticoid sensitivity to enable dosage reduction. Macrophage migration inhibitory factor (MIF) is a proinflammatory protein th...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2014-08, Vol.66 (8), p.2059-2070
Hauptverfasser:	Fan, Huapeng, Kao, Wenping, Yang, Yuan H., Gu, Ran, Harris, James, Fingerle‐Rowson, Günter, Bucala, Richard, Ngo, Devi, Beaulieu, Elaine, Morand, Eric F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Dual Specificity Phosphatase 1 - drug effects Dual Specificity Phosphatase 1 - physiology Glucocorticoids - pharmacology Leucine Zippers - drug effects Leucine Zippers - physiology Macrophage Migration-Inhibitory Factors - physiology Male Medical research Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - physiology
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