Effect of Photodynamic Therapy on Cisterna Chyli Patency in Rats
OBJECTIVE: To radiographically and histologically evaluate the effects of photodynamic therapy on the cisterna chyli in rats. STUDY DESIGN: Experimental study. ANIMALS: Adult male Sprague‐Dawley rats (n = 60). METHODS: Cecal lymph nodes were injected with the photodynamic compound verteporfin. A 690...
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| Veröffentlicht in: | Veterinary surgery 2014-08, Vol.43 (6), p.642-649 |
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| creator | Rowe, Eric A Mathews, Kyle G Linder, Keith E Tate, Lloyd P |
| description | OBJECTIVE: To radiographically and histologically evaluate the effects of photodynamic therapy on the cisterna chyli in rats. STUDY DESIGN: Experimental study. ANIMALS: Adult male Sprague‐Dawley rats (n = 60). METHODS: Cecal lymph nodes were injected with the photodynamic compound verteporfin. A 690 nm, 500 mW diode laser was then directed at the area of the cisterna chyli for either 0, 1.5, or 3 minutes. Cisterna chyli patency was evaluated using lymphography, and histologic changes were evaluated on postoperative Days 1, 3, 5, 7, and 14. RESULTS: Histologically, minimal to marked injury to the cisternal and/or pericisternal tissues was present in all treated rats at all time periods. Radiographically, 8/20 cisternae were occluded in the 1.5‐minute treatment group (including 1/4 on Day 1, 2/4 on Day 3, 3/4 on Day 5, 0/4 on Day 7, and 2/4 on Day 14), and 9/20 cisternae were occluded in the 3‐minute treatment group (including 0/4 on Day 1, 1/4 on Day 3, 3/4 on Day 5, 3/4 on Day 7, and 2/4 on Day 14). There was minimal to no histologic evidence of tissue injury in control rats. All control cisternae were radiographically open. CONCLUSIONS: Further investigations into the timing of laser application and light dose, or alternative photodynamic agents are required to limit injury to adjacent tissues and to improve the effectiveness of cisternal photoablation. |
| doi_str_mv | 10.1111/j.1532-950X.2014.12222.x |
| format | Article |
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STUDY DESIGN: Experimental study. ANIMALS: Adult male Sprague‐Dawley rats (n = 60). METHODS: Cecal lymph nodes were injected with the photodynamic compound verteporfin. A 690 nm, 500 mW diode laser was then directed at the area of the cisterna chyli for either 0, 1.5, or 3 minutes. Cisterna chyli patency was evaluated using lymphography, and histologic changes were evaluated on postoperative Days 1, 3, 5, 7, and 14. RESULTS: Histologically, minimal to marked injury to the cisternal and/or pericisternal tissues was present in all treated rats at all time periods. Radiographically, 8/20 cisternae were occluded in the 1.5‐minute treatment group (including 1/4 on Day 1, 2/4 on Day 3, 3/4 on Day 5, 0/4 on Day 7, and 2/4 on Day 14), and 9/20 cisternae were occluded in the 3‐minute treatment group (including 0/4 on Day 1, 1/4 on Day 3, 3/4 on Day 5, 3/4 on Day 7, and 2/4 on Day 14). There was minimal to no histologic evidence of tissue injury in control rats. All control cisternae were radiographically open. CONCLUSIONS: Further investigations into the timing of laser application and light dose, or alternative photodynamic agents are required to limit injury to adjacent tissues and to improve the effectiveness of cisternal photoablation.</description><identifier>ISSN: 0161-3499</identifier><identifier>EISSN: 1532-950X</identifier><identifier>DOI: 10.1111/j.1532-950X.2014.12222.x</identifier><identifier>PMID: 24909350</identifier><language>eng</language><publisher>United States: Harcourt Health Sciences</publisher><subject>adults ; Animals ; Dose-Response Relationship, Drug ; experimental design ; Injections ; Lymph Nodes ; Lymphography ; Male ; Photochemotherapy ; Photodynamic therapy ; Photosensitizing Agents - pharmacology ; Phytotherapy ; Porphyrins - pharmacology ; Rats ; Rats, Sprague-Dawley ; Rodents ; therapeutics ; Thoracic Duct - diagnostic imaging ; Thoracic Duct - drug effects ; Thoracic Duct - pathology</subject><ispartof>Veterinary surgery, 2014-08, Vol.43 (6), p.642-649</ispartof><rights>Copyright 2014 by The American College of Veterinary Surgeons</rights><rights>Copyright 2014 by The American College of Veterinary Surgeons.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4752-917b8123d670cbd462385a79c2c0757503ca075071535a5f89a267c1b1d890c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-950X.2014.12222.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-950X.2014.12222.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24909350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rowe, Eric A</creatorcontrib><creatorcontrib>Mathews, Kyle G</creatorcontrib><creatorcontrib>Linder, Keith E</creatorcontrib><creatorcontrib>Tate, Lloyd P</creatorcontrib><title>Effect of Photodynamic Therapy on Cisterna Chyli Patency in Rats</title><title>Veterinary surgery</title><addtitle>Veterinary Surgery</addtitle><description>OBJECTIVE: To radiographically and histologically evaluate the effects of photodynamic therapy on the cisterna chyli in rats. STUDY DESIGN: Experimental study. ANIMALS: Adult male Sprague‐Dawley rats (n = 60). METHODS: Cecal lymph nodes were injected with the photodynamic compound verteporfin. A 690 nm, 500 mW diode laser was then directed at the area of the cisterna chyli for either 0, 1.5, or 3 minutes. Cisterna chyli patency was evaluated using lymphography, and histologic changes were evaluated on postoperative Days 1, 3, 5, 7, and 14. RESULTS: Histologically, minimal to marked injury to the cisternal and/or pericisternal tissues was present in all treated rats at all time periods. Radiographically, 8/20 cisternae were occluded in the 1.5‐minute treatment group (including 1/4 on Day 1, 2/4 on Day 3, 3/4 on Day 5, 0/4 on Day 7, and 2/4 on Day 14), and 9/20 cisternae were occluded in the 3‐minute treatment group (including 0/4 on Day 1, 1/4 on Day 3, 3/4 on Day 5, 3/4 on Day 7, and 2/4 on Day 14). There was minimal to no histologic evidence of tissue injury in control rats. All control cisternae were radiographically open. CONCLUSIONS: Further investigations into the timing of laser application and light dose, or alternative photodynamic agents are required to limit injury to adjacent tissues and to improve the effectiveness of cisternal photoablation.</description><subject>adults</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>experimental design</subject><subject>Injections</subject><subject>Lymph Nodes</subject><subject>Lymphography</subject><subject>Male</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Phytotherapy</subject><subject>Porphyrins - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>therapeutics</subject><subject>Thoracic Duct - diagnostic imaging</subject><subject>Thoracic Duct - drug effects</subject><subject>Thoracic Duct - pathology</subject><issn>0161-3499</issn><issn>1532-950X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9v0zAUxy0EYqXwL4AlLlySPf-K4wtiKtuYNG0VXWE3y3UcmpLGJU615r_HWUYPnPYutuTP-77nD0KYQEpinW5SIhhNlID7lALhKaGx0sMLNDk-vEQTIBlJGFfqBL0JYQMAinP2Gp1QrkAxARP05bwsne2wL_F87Ttf9I3ZVhbfrV1rdj32DZ5VoXNtY_Bs3dcVnpvONbbHVYO_my68Ra9KUwf37umcouXF-d3sW3J9e3k1O7tOLJcibkTkKieUFZkEuyp4RlkujFSWWpBCCmDWxAvIuL8wosyVoZm0ZEWKXIHN2BR9GnN3rf-zd6HT2ypYV9emcX4fNBFcZSzKkBH9-B-68fv4gXqgBCMCaJw3RflI2daH0LpS79pqa9peE9CDZb3Rg0w9yNSDZf1oWR9i6_unAfvV1hXHxn9aI_B5BB6q2vXPDtY_FsvHawxIxoDB_eEYYNrfOpNMCv3z5lJnC57ffBX3eh75DyNfGq_Nr7YKerkYogGIoAwY-wu_2Z_5</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Rowe, Eric A</creator><creator>Mathews, Kyle G</creator><creator>Linder, Keith E</creator><creator>Tate, Lloyd P</creator><general>Harcourt Health Sciences</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Effect of Photodynamic Therapy on Cisterna Chyli Patency in Rats</title><author>Rowe, Eric A ; Mathews, Kyle G ; Linder, Keith E ; Tate, Lloyd P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4752-917b8123d670cbd462385a79c2c0757503ca075071535a5f89a267c1b1d890c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>adults</topic><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>experimental design</topic><topic>Injections</topic><topic>Lymph Nodes</topic><topic>Lymphography</topic><topic>Male</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Phytotherapy</topic><topic>Porphyrins - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>therapeutics</topic><topic>Thoracic Duct - diagnostic imaging</topic><topic>Thoracic Duct - drug effects</topic><topic>Thoracic Duct - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowe, Eric A</creatorcontrib><creatorcontrib>Mathews, Kyle G</creatorcontrib><creatorcontrib>Linder, Keith E</creatorcontrib><creatorcontrib>Tate, Lloyd P</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowe, Eric A</au><au>Mathews, Kyle G</au><au>Linder, Keith E</au><au>Tate, Lloyd P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Photodynamic Therapy on Cisterna Chyli Patency in Rats</atitle><jtitle>Veterinary surgery</jtitle><addtitle>Veterinary Surgery</addtitle><date>2014-08</date><risdate>2014</risdate><volume>43</volume><issue>6</issue><spage>642</spage><epage>649</epage><pages>642-649</pages><issn>0161-3499</issn><eissn>1532-950X</eissn><abstract>OBJECTIVE: To radiographically and histologically evaluate the effects of photodynamic therapy on the cisterna chyli in rats. STUDY DESIGN: Experimental study. ANIMALS: Adult male Sprague‐Dawley rats (n = 60). METHODS: Cecal lymph nodes were injected with the photodynamic compound verteporfin. A 690 nm, 500 mW diode laser was then directed at the area of the cisterna chyli for either 0, 1.5, or 3 minutes. Cisterna chyli patency was evaluated using lymphography, and histologic changes were evaluated on postoperative Days 1, 3, 5, 7, and 14. RESULTS: Histologically, minimal to marked injury to the cisternal and/or pericisternal tissues was present in all treated rats at all time periods. Radiographically, 8/20 cisternae were occluded in the 1.5‐minute treatment group (including 1/4 on Day 1, 2/4 on Day 3, 3/4 on Day 5, 0/4 on Day 7, and 2/4 on Day 14), and 9/20 cisternae were occluded in the 3‐minute treatment group (including 0/4 on Day 1, 1/4 on Day 3, 3/4 on Day 5, 3/4 on Day 7, and 2/4 on Day 14). There was minimal to no histologic evidence of tissue injury in control rats. All control cisternae were radiographically open. CONCLUSIONS: Further investigations into the timing of laser application and light dose, or alternative photodynamic agents are required to limit injury to adjacent tissues and to improve the effectiveness of cisternal photoablation.</abstract><cop>United States</cop><pub>Harcourt Health Sciences</pub><pmid>24909350</pmid><doi>10.1111/j.1532-950X.2014.12222.x</doi><tpages>8</tpages></addata></record> |
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| subjects | adults Animals Dose-Response Relationship, Drug experimental design Injections Lymph Nodes Lymphography Male Photochemotherapy Photodynamic therapy Photosensitizing Agents - pharmacology Phytotherapy Porphyrins - pharmacology Rats Rats, Sprague-Dawley Rodents therapeutics Thoracic Duct - diagnostic imaging Thoracic Duct - drug effects Thoracic Duct - pathology |
| title | Effect of Photodynamic Therapy on Cisterna Chyli Patency in Rats |
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