Persistent Cognitive Impairment After Transient Ischemic Attack
BACKGROUND AND PURPOSE—By definition, the symptoms of a transient ischemic attack (TIA) subside completely within 24 hours. Imaging studies show signs of persistent ischemic tissue damage in a substantial amount of patients with TIA. Cerebral infarction can cause permanent cognitive impairment. Whet...
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| Veröffentlicht in: | Stroke (1970) 2014-08, Vol.45 (8), p.2270-2274 |
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| container_title | Stroke (1970) |
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| creator | van Rooij, Frank G Schaapsmeerders, Pauline Maaijwee, Noortje A.M van Duijnhoven, Dirk A.H.J de Leeuw, Frank-Erik Kessels, Roy P.C van Dijk, Ewoud J |
| description | BACKGROUND AND PURPOSE—By definition, the symptoms of a transient ischemic attack (TIA) subside completely within 24 hours. Imaging studies show signs of persistent ischemic tissue damage in a substantial amount of patients with TIA. Cerebral infarction can cause permanent cognitive impairment. Whether permanent cognitive impairment occurs after TIA is unclear, as is its profile.
METHODS—Patients with TIA aged 45 to 65 years without prior stroke or dementia underwent comprehensive neuropsychological testing within 3 months. Z scores per cognitive domain were obtained, based on the mean of a control group within the same age range. Cognitive impairment was defined as a domain z score |
| doi_str_mv | 10.1161/STROKEAHA.114.005205 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1549631998</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1549631998</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5025-3e29f8ef8c9cedc1b55ea1a05f7cfda6b511dafe94de8c1ce0b473f8ba833fa73</originalsourceid><addsrcrecordid>eNp9kF1PwjAUhhujEfz4B8ZwY-LN8HRrWXtlFoJCJMEoXi9ddyqVjWG7Sfz3joB459XJe_KcjzyEXFHoUzqgd6_zl9nTKBknbWR9AB4CPyJdykMWsEEojkkXIJJByKTskDPvPwAgjAQ_JZ2QQwySyy65f0bnra9xVfeG1fvK1vYLe5Nyrawrt83E1Oh6c6dW3m7zxOsFllb3krpWenlBTowqPF7u6zl5exjNh-NgOnucDJNpoDmEPIgwlEagEVpqzDXNOEdFFXATa5OrQcYpzZVByXIUmmqEjMWREZkSUWRUHJ2T293etas-G_R1WlqvsSjUCqvGp5QzOYiolKJF2Q7VrvLeoUnXzpbKfacU0q269KCujSzdqWvHrvcXmqzE_DD066oFbvaA8loVplWirf_jRAwMYtpyYsdtqqJ155dFs0GXLlAV9eL_H34A3ZOKhQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1549631998</pqid></control><display><type>article</type><title>Persistent Cognitive Impairment After Transient Ischemic Attack</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>van Rooij, Frank G ; Schaapsmeerders, Pauline ; Maaijwee, Noortje A.M ; van Duijnhoven, Dirk A.H.J ; de Leeuw, Frank-Erik ; Kessels, Roy P.C ; van Dijk, Ewoud J</creator><creatorcontrib>van Rooij, Frank G ; Schaapsmeerders, Pauline ; Maaijwee, Noortje A.M ; van Duijnhoven, Dirk A.H.J ; de Leeuw, Frank-Erik ; Kessels, Roy P.C ; van Dijk, Ewoud J</creatorcontrib><description>BACKGROUND AND PURPOSE—By definition, the symptoms of a transient ischemic attack (TIA) subside completely within 24 hours. Imaging studies show signs of persistent ischemic tissue damage in a substantial amount of patients with TIA. Cerebral infarction can cause permanent cognitive impairment. Whether permanent cognitive impairment occurs after TIA is unclear, as is its profile.
METHODS—Patients with TIA aged 45 to 65 years without prior stroke or dementia underwent comprehensive neuropsychological testing within 3 months. Z scores per cognitive domain were obtained, based on the mean of a control group within the same age range. Cognitive impairment was defined as a domain z score <−1.65. Patients underwent either computed tomography or MRI brain imaging.
RESULTS—One hundred seven patients with TIA (63% women, mean age, 56.6 years) were included and compared with 81 controls (56% women, mean age, 52.9 years). Patients performed worse on all cognitive domains except episodic memory. Working memory (25%), attention (22%), and information processing speed (16%) were most frequently impaired and more often than in the control group (age- and sex-adjusted odds ratios, respectively, 22.5 [95% confidence interval, 2.9–174.3], 6.8 [1.9–24.3], 7.1 [1.5–32.5]). More than 35% of patients with TIA had impairment of ≥1 cognitive domain. Presence of silent brain infarcts was related to worse executive functioning but did not explain the whole relationship between TIA and cognitive impairment.
CONCLUSIONS—More than a third of patients with TIA have impairment of ≥1 cognitive domain within 3 months after their TIA. The affected domains fit in the vascular cognitive impairment profile.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.114.005205</identifier><identifier>PMID: 25070959</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Aged ; Attention ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain - diagnostic imaging ; Brain - pathology ; Cognition ; Cognition Disorders - diagnostic imaging ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Cognition Disorders - psychology ; Executive Function ; Female ; Humans ; Ischemic Attack, Transient - complications ; Ischemic Attack, Transient - diagnostic imaging ; Ischemic Attack, Transient - pathology ; Ischemic Attack, Transient - psychology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory, Short-Term ; Middle Aged ; Neurology ; Neuropsychological Tests ; Pharmacology. Drug treatments ; Radiography ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2014-08, Vol.45 (8), p.2270-2274</ispartof><rights>2014 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5025-3e29f8ef8c9cedc1b55ea1a05f7cfda6b511dafe94de8c1ce0b473f8ba833fa73</citedby><cites>FETCH-LOGICAL-c5025-3e29f8ef8c9cedc1b55ea1a05f7cfda6b511dafe94de8c1ce0b473f8ba833fa73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28704071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25070959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Rooij, Frank G</creatorcontrib><creatorcontrib>Schaapsmeerders, Pauline</creatorcontrib><creatorcontrib>Maaijwee, Noortje A.M</creatorcontrib><creatorcontrib>van Duijnhoven, Dirk A.H.J</creatorcontrib><creatorcontrib>de Leeuw, Frank-Erik</creatorcontrib><creatorcontrib>Kessels, Roy P.C</creatorcontrib><creatorcontrib>van Dijk, Ewoud J</creatorcontrib><title>Persistent Cognitive Impairment After Transient Ischemic Attack</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—By definition, the symptoms of a transient ischemic attack (TIA) subside completely within 24 hours. Imaging studies show signs of persistent ischemic tissue damage in a substantial amount of patients with TIA. Cerebral infarction can cause permanent cognitive impairment. Whether permanent cognitive impairment occurs after TIA is unclear, as is its profile.
METHODS—Patients with TIA aged 45 to 65 years without prior stroke or dementia underwent comprehensive neuropsychological testing within 3 months. Z scores per cognitive domain were obtained, based on the mean of a control group within the same age range. Cognitive impairment was defined as a domain z score <−1.65. Patients underwent either computed tomography or MRI brain imaging.
RESULTS—One hundred seven patients with TIA (63% women, mean age, 56.6 years) were included and compared with 81 controls (56% women, mean age, 52.9 years). Patients performed worse on all cognitive domains except episodic memory. Working memory (25%), attention (22%), and information processing speed (16%) were most frequently impaired and more often than in the control group (age- and sex-adjusted odds ratios, respectively, 22.5 [95% confidence interval, 2.9–174.3], 6.8 [1.9–24.3], 7.1 [1.5–32.5]). More than 35% of patients with TIA had impairment of ≥1 cognitive domain. Presence of silent brain infarcts was related to worse executive functioning but did not explain the whole relationship between TIA and cognitive impairment.
CONCLUSIONS—More than a third of patients with TIA have impairment of ≥1 cognitive domain within 3 months after their TIA. The affected domains fit in the vascular cognitive impairment profile.</description><subject>Aged</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Cognition</subject><subject>Cognition Disorders - diagnostic imaging</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - psychology</subject><subject>Executive Function</subject><subject>Female</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - complications</subject><subject>Ischemic Attack, Transient - diagnostic imaging</subject><subject>Ischemic Attack, Transient - pathology</subject><subject>Ischemic Attack, Transient - psychology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiography</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1PwjAUhhujEfz4B8ZwY-LN8HRrWXtlFoJCJMEoXi9ddyqVjWG7Sfz3joB459XJe_KcjzyEXFHoUzqgd6_zl9nTKBknbWR9AB4CPyJdykMWsEEojkkXIJJByKTskDPvPwAgjAQ_JZ2QQwySyy65f0bnra9xVfeG1fvK1vYLe5Nyrawrt83E1Oh6c6dW3m7zxOsFllb3krpWenlBTowqPF7u6zl5exjNh-NgOnucDJNpoDmEPIgwlEagEVpqzDXNOEdFFXATa5OrQcYpzZVByXIUmmqEjMWREZkSUWRUHJ2T293etas-G_R1WlqvsSjUCqvGp5QzOYiolKJF2Q7VrvLeoUnXzpbKfacU0q269KCujSzdqWvHrvcXmqzE_DD066oFbvaA8loVplWirf_jRAwMYtpyYsdtqqJ155dFs0GXLlAV9eL_H34A3ZOKhQ</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>van Rooij, Frank G</creator><creator>Schaapsmeerders, Pauline</creator><creator>Maaijwee, Noortje A.M</creator><creator>van Duijnhoven, Dirk A.H.J</creator><creator>de Leeuw, Frank-Erik</creator><creator>Kessels, Roy P.C</creator><creator>van Dijk, Ewoud J</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Persistent Cognitive Impairment After Transient Ischemic Attack</title><author>van Rooij, Frank G ; Schaapsmeerders, Pauline ; Maaijwee, Noortje A.M ; van Duijnhoven, Dirk A.H.J ; de Leeuw, Frank-Erik ; Kessels, Roy P.C ; van Dijk, Ewoud J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5025-3e29f8ef8c9cedc1b55ea1a05f7cfda6b511dafe94de8c1ce0b473f8ba833fa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Attention</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Cognition</topic><topic>Cognition Disorders - diagnostic imaging</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - psychology</topic><topic>Executive Function</topic><topic>Female</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - complications</topic><topic>Ischemic Attack, Transient - diagnostic imaging</topic><topic>Ischemic Attack, Transient - pathology</topic><topic>Ischemic Attack, Transient - psychology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory, Short-Term</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiography</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Rooij, Frank G</creatorcontrib><creatorcontrib>Schaapsmeerders, Pauline</creatorcontrib><creatorcontrib>Maaijwee, Noortje A.M</creatorcontrib><creatorcontrib>van Duijnhoven, Dirk A.H.J</creatorcontrib><creatorcontrib>de Leeuw, Frank-Erik</creatorcontrib><creatorcontrib>Kessels, Roy P.C</creatorcontrib><creatorcontrib>van Dijk, Ewoud J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Rooij, Frank G</au><au>Schaapsmeerders, Pauline</au><au>Maaijwee, Noortje A.M</au><au>van Duijnhoven, Dirk A.H.J</au><au>de Leeuw, Frank-Erik</au><au>Kessels, Roy P.C</au><au>van Dijk, Ewoud J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent Cognitive Impairment After Transient Ischemic Attack</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2014-08</date><risdate>2014</risdate><volume>45</volume><issue>8</issue><spage>2270</spage><epage>2274</epage><pages>2270-2274</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>BACKGROUND AND PURPOSE—By definition, the symptoms of a transient ischemic attack (TIA) subside completely within 24 hours. Imaging studies show signs of persistent ischemic tissue damage in a substantial amount of patients with TIA. Cerebral infarction can cause permanent cognitive impairment. Whether permanent cognitive impairment occurs after TIA is unclear, as is its profile.
METHODS—Patients with TIA aged 45 to 65 years without prior stroke or dementia underwent comprehensive neuropsychological testing within 3 months. Z scores per cognitive domain were obtained, based on the mean of a control group within the same age range. Cognitive impairment was defined as a domain z score <−1.65. Patients underwent either computed tomography or MRI brain imaging.
RESULTS—One hundred seven patients with TIA (63% women, mean age, 56.6 years) were included and compared with 81 controls (56% women, mean age, 52.9 years). Patients performed worse on all cognitive domains except episodic memory. Working memory (25%), attention (22%), and information processing speed (16%) were most frequently impaired and more often than in the control group (age- and sex-adjusted odds ratios, respectively, 22.5 [95% confidence interval, 2.9–174.3], 6.8 [1.9–24.3], 7.1 [1.5–32.5]). More than 35% of patients with TIA had impairment of ≥1 cognitive domain. Presence of silent brain infarcts was related to worse executive functioning but did not explain the whole relationship between TIA and cognitive impairment.
CONCLUSIONS—More than a third of patients with TIA have impairment of ≥1 cognitive domain within 3 months after their TIA. The affected domains fit in the vascular cognitive impairment profile.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>25070959</pmid><doi>10.1161/STROKEAHA.114.005205</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Attention Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain - diagnostic imaging Brain - pathology Cognition Cognition Disorders - diagnostic imaging Cognition Disorders - etiology Cognition Disorders - pathology Cognition Disorders - psychology Executive Function Female Humans Ischemic Attack, Transient - complications Ischemic Attack, Transient - diagnostic imaging Ischemic Attack, Transient - pathology Ischemic Attack, Transient - psychology Magnetic Resonance Imaging Male Medical sciences Memory, Short-Term Middle Aged Neurology Neuropsychological Tests Pharmacology. Drug treatments Radiography Vascular diseases and vascular malformations of the nervous system |
| title | Persistent Cognitive Impairment After Transient Ischemic Attack |
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