New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans
The antifungal activity of the saponin-rich fractions (SFs) from Medicago sativa (aerial parts and roots) and Saponaria officinalis (used as a well-known source of plant saponins) against Candida albicans reference and clinical strains, their yeast-to-hyphal conversion, adhesion, and biofilm formati...
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| Veröffentlicht in: | Journal of medical microbiology 2014-08, Vol.63 (8), p.1076-1086 |
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| creator | SADOWSKA, Beata BUDZYNSKA, Aleksandra WECKOWSKA-SZAKE, Marzena PASZKIEWICZ, Małgorzata STOCHMAL, Anna MONIUSZKO-SZAJWAJ, Barbara KOWALCZYK, Mariusz ROZALSKA, Barbara |
| description | The antifungal activity of the saponin-rich fractions (SFs) from Medicago sativa (aerial parts and roots) and Saponaria officinalis (used as a well-known source of plant saponins) against Candida albicans reference and clinical strains, their yeast-to-hyphal conversion, adhesion, and biofilm formation was investigated. Direct fungicidal/fungistatic properties of the tested phytochemicals used alone, as well as their synergy with azoles (probably resulting from yeast cell wall instability) were demonstrated. Here, to the best of our knowledge, we report for the first time the ability of saponin-rich extracts of M. sativa and S. officinalis to inhibit C. albicans germ tube formation, limit hyphal growth, reduce yeast adherence and biofilm formation, and eradicate mature (24 h) Candida biofilm. Moreover, M. sativa SFs (mainly obtained from aerial parts), in the range of concentrations which were active modulators of Candida virulence factors, exhibited low cytotoxicity against the mouse fibroblast line L929. These properties seem to be very promising in the context of using plant-derived SFs as potential novel antifungal therapeutics supporting classic drugs or as ingredients of disinfectants. |
| doi_str_mv | 10.1099/jmm.0.075291-0 |
| format | Article |
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Direct fungicidal/fungistatic properties of the tested phytochemicals used alone, as well as their synergy with azoles (probably resulting from yeast cell wall instability) were demonstrated. Here, to the best of our knowledge, we report for the first time the ability of saponin-rich extracts of M. sativa and S. officinalis to inhibit C. albicans germ tube formation, limit hyphal growth, reduce yeast adherence and biofilm formation, and eradicate mature (24 h) Candida biofilm. Moreover, M. sativa SFs (mainly obtained from aerial parts), in the range of concentrations which were active modulators of Candida virulence factors, exhibited low cytotoxicity against the mouse fibroblast line L929. 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Direct fungicidal/fungistatic properties of the tested phytochemicals used alone, as well as their synergy with azoles (probably resulting from yeast cell wall instability) were demonstrated. Here, to the best of our knowledge, we report for the first time the ability of saponin-rich extracts of M. sativa and S. officinalis to inhibit C. albicans germ tube formation, limit hyphal growth, reduce yeast adherence and biofilm formation, and eradicate mature (24 h) Candida biofilm. Moreover, M. sativa SFs (mainly obtained from aerial parts), in the range of concentrations which were active modulators of Candida virulence factors, exhibited low cytotoxicity against the mouse fibroblast line L929. These properties seem to be very promising in the context of using plant-derived SFs as potential novel antifungal therapeutics supporting classic drugs or as ingredients of disinfectants.</description><subject>Animals</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biofilms - drug effects</subject><subject>Biological and medical sciences</subject><subject>Candida albicans - drug effects</subject><subject>Cell Line</subject><subject>Cell Wall - drug effects</subject><subject>Fibroblasts</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Infectious diseases</subject><subject>Medicago sativa - chemistry</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mycology</subject><subject>Oxidative Stress</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Saponaria - chemistry</subject><subject>Saponins - chemistry</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEuLFDEUhYM4OG3r1qVkI7ipNs9KZSmNLxjHhboOt_OYyVBVKXOrHdzNTzfSra4uHL5z4H6EvOBsx5m1b-6macd2zGhheccekQ1XRna6V-ox2TAmRCd6ri_JU8Q7xriR0j4hl0INmg3GbsjDdbynyy3UCXwZy032MNKlliXWNUekJdHPMbT0plCENf8ECnOgX2EpM9QMDUjZ5xnGjA1oaZ67mv0tTRX8msuMFEKoETEGuha6b_Uc2sp4aKszPiMXCUaMz893S76_f_dt_7G7-vLh0_7tVeel0GvXMxN6BdwbnYzy0XotEkilBCRtjR70kJSVKgyWxchikgM_hEEnlfoovZJb8vq02577cYy4uimjj-MIcyxHdFwr20vOmr4t2Z1QXwtijcktNU9QfznO3B_rrll3zJ2sO9YKL8_bx8MUwz_8r-YGvDoDgE1wUzP7jP-5oTfC9kL-Bk_KjQI</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>SADOWSKA, Beata</creator><creator>BUDZYNSKA, Aleksandra</creator><creator>WECKOWSKA-SZAKE, Marzena</creator><creator>PASZKIEWICZ, Małgorzata</creator><creator>STOCHMAL, Anna</creator><creator>MONIUSZKO-SZAJWAJ, Barbara</creator><creator>KOWALCZYK, Mariusz</creator><creator>ROZALSKA, Barbara</creator><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans</title><author>SADOWSKA, Beata ; BUDZYNSKA, Aleksandra ; WECKOWSKA-SZAKE, Marzena ; PASZKIEWICZ, Małgorzata ; STOCHMAL, Anna ; MONIUSZKO-SZAJWAJ, Barbara ; KOWALCZYK, Mariusz ; ROZALSKA, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-607d64a1c75f74ce9c52fa3442af5975858f4934d890ee0ef381bd85f4f6e3c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Biofilms - drug effects</topic><topic>Biological and medical sciences</topic><topic>Candida albicans - drug effects</topic><topic>Cell Line</topic><topic>Cell Wall - drug effects</topic><topic>Fibroblasts</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Infectious diseases</topic><topic>Medicago sativa - chemistry</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mycology</topic><topic>Oxidative Stress</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Saponaria - chemistry</topic><topic>Saponins - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SADOWSKA, Beata</creatorcontrib><creatorcontrib>BUDZYNSKA, Aleksandra</creatorcontrib><creatorcontrib>WECKOWSKA-SZAKE, Marzena</creatorcontrib><creatorcontrib>PASZKIEWICZ, Małgorzata</creatorcontrib><creatorcontrib>STOCHMAL, Anna</creatorcontrib><creatorcontrib>MONIUSZKO-SZAJWAJ, Barbara</creatorcontrib><creatorcontrib>KOWALCZYK, Mariusz</creatorcontrib><creatorcontrib>ROZALSKA, Barbara</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SADOWSKA, Beata</au><au>BUDZYNSKA, Aleksandra</au><au>WECKOWSKA-SZAKE, Marzena</au><au>PASZKIEWICZ, Małgorzata</au><au>STOCHMAL, Anna</au><au>MONIUSZKO-SZAJWAJ, Barbara</au><au>KOWALCZYK, Mariusz</au><au>ROZALSKA, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>63</volume><issue>8</issue><spage>1076</spage><epage>1086</epage><pages>1076-1086</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><coden>JMMIAV</coden><abstract>The antifungal activity of the saponin-rich fractions (SFs) from Medicago sativa (aerial parts and roots) and Saponaria officinalis (used as a well-known source of plant saponins) against Candida albicans reference and clinical strains, their yeast-to-hyphal conversion, adhesion, and biofilm formation was investigated. Direct fungicidal/fungistatic properties of the tested phytochemicals used alone, as well as their synergy with azoles (probably resulting from yeast cell wall instability) were demonstrated. Here, to the best of our knowledge, we report for the first time the ability of saponin-rich extracts of M. sativa and S. officinalis to inhibit C. albicans germ tube formation, limit hyphal growth, reduce yeast adherence and biofilm formation, and eradicate mature (24 h) Candida biofilm. Moreover, M. sativa SFs (mainly obtained from aerial parts), in the range of concentrations which were active modulators of Candida virulence factors, exhibited low cytotoxicity against the mouse fibroblast line L929. These properties seem to be very promising in the context of using plant-derived SFs as potential novel antifungal therapeutics supporting classic drugs or as ingredients of disinfectants.</abstract><cop>Reading</cop><pub>Society for General Microbiology</pub><pmid>24850879</pmid><doi>10.1099/jmm.0.075291-0</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Antifungal Agents - chemistry Antifungal Agents - pharmacology Biofilms - drug effects Biological and medical sciences Candida albicans - drug effects Cell Line Cell Wall - drug effects Fibroblasts Fundamental and applied biological sciences. Psychology Infectious diseases Medicago sativa - chemistry Medical sciences Mice Microbiology Miscellaneous Mycology Oxidative Stress Plant Extracts - chemistry Plant Extracts - pharmacology Saponaria - chemistry Saponins - chemistry |
| title | New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans |
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