The E3 Ubiquitin Ligase gp78 Protects against ER Stress in Zebrafish Liver

Enhanced endoplasmic reticulum （ER）-associated protein degradation （ERAD） activity by the unfolded protein response （UPR） represents one of the mechanisms for restoring ER homeostasis. In vitro evidence indicates that the mammalian gp78 protein is an E3 ubiquitin ligase that facilitates ERAD by poly...

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Veröffentlicht in:	Journal of genetics and genomics 2014-07, Vol.41 (7), p.357-368
Hauptverfasser:	Chen, Zhiliang, Ballar, Petek, Fu, Yu, Luo, Jia, Du, Shaojun, Fang, Shengyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cholesterol Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects ERAD gp78/AMFR Homeostasis - drug effects Humans Larva - cytology Larva - drug effects Larva - enzymology Larva - metabolism Lipid Metabolism - drug effects Lipogenesis Liver - cytology Liver - embryology Liver - enzymology Liver - metabolism Molecular Sequence Data Protein Transport - drug effects Sterol Regulatory Element Binding Proteins - genetics Tunicamycin - pharmacology Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Up-Regulation - drug effects UPR Zebrafish Zebrafish - embryology 保护内质网应激哺乳动物斑马鱼泛素连接酶特异性表达肝脏蛋白质降解
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