Near-Infrared and Fourier Transform Infrared Chemometric Methods for the Quantification of Crystalline Tacrolimus from Sustained-Release Amorphous Solid Dispersion

The objective of the present research was to study the feasibility of using near-infrared (NIR) and Fourier transform infrared (FTIR)-based chemometric models in quantifying crystalline and amorphous tacrolimus from its sustained-release amorphous solid dispersion (ASD). ASD contained ethyl cellulos...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2014-08, Vol.103 (8), p.2376-2385
Hauptverfasser:	Rahman, Ziyaur, Siddiqui, Akhtar, Bykadi, Srikant, Khan, Mansoor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	amorphous chemometrics crystallinity Crystallization Delayed-Action Preparations - chemistry Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - chemistry infrared spectroscopy Least-Squares Analysis near-infrared spectroscopy partial least squares Principal Component Analysis solid dispersion Spectroscopy, Fourier Transform Infrared - methods Spectroscopy, Near-Infrared - methods Tacrolimus - administration & dosage Tacrolimus - chemistry
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