The red cell distribution width (RDW): Value and role in preterm, IUGR (intrauterine growth restricted), full-term infants
Objective To measure the red cell distribution width (RDW) ranges at birth and to evaluate potential association with typical neonatal diseases: patent of the ductus arteriousus (PDA), bronchopulmonary dysplasia (BPD), and late-onset sepsis (LOS) mortality. Methods Forty-six full-term, 41 preterm, a...
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| Veröffentlicht in: | Hematology (Luxembourg) 2014-09, Vol.19 (6), p.365-369 |
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| creator | Garofoli, Francesca Ciardelli, Laura Mazzucchelli, Iolanda Borghesi, Alessandro Angelini, Micol Bollani, Lina Genini, Emilia Manzoni, Paolo Paolillo, Piermichele Tinelli, Carmine Merlini, Giampaolo Stronati, Mauro |
| description | Objective
To measure the red cell distribution width (RDW) ranges at birth and to evaluate potential association with typical neonatal diseases: patent of the ductus arteriousus (PDA), bronchopulmonary dysplasia (BPD), and late-onset sepsis (LOS) mortality.
Methods
Forty-six full-term, 41 preterm, and 35 intrauterine growth restricted (IUGR) infants participated in this retrospective, observational study. RDW was measured before 3 days of life (T0) in all infants, and at first month of life (T1) in preterm/IURG patients.
Results
RDW% mean (standard deviation) at T0 was: 15.65 (1.18) in full-term newborns; 17.7 (2.06) in preterm; 17.45 (1.81) in IUGR. A negative correlation (r = −0.51; P < 0.001) between RDW and gestational age was found. RDW at T1 was: 17.25 (2.19) in the preterm group; 17.37 (2.56) in IUGR group. Fourteen preterm infants reported: 12 PDA, 5 LOS, 4 BPD, and 3 died; 10 IUGR infants had: 4 PDA, 6 LOS, 3 BPD, and 1 died.
RDW of IUGR infants suffering from those pathologies was not statistically different compared with unaffected infants, while preterm newborns with pathologies reported higher RDW: PDA vs. PDA absent: P = 0.008 at T0; P < 0.002 at T1. BPD vs. BPD absent: P < 0.005 at T1. LOS vs. LOS absent: P < 0.005 at T0.
RDW in preterm/IUGR population was associated with early mortality, T0: dead 21.2 (2.7) vs. alive 16.7 (1.7), P < 0.0001.
Conclusion
RDW and gestational age at birth were negatively correlated. High RDW resulted to be an indication of risk for critical newborns. This parameter can be inexpensively and routinely verified and further studies are required to confirm its prognostic role in neonatal pathologies. |
| doi_str_mv | 10.1179/1607845413Y.0000000141 |
| format | Article |
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To measure the red cell distribution width (RDW) ranges at birth and to evaluate potential association with typical neonatal diseases: patent of the ductus arteriousus (PDA), bronchopulmonary dysplasia (BPD), and late-onset sepsis (LOS) mortality.
Methods
Forty-six full-term, 41 preterm, and 35 intrauterine growth restricted (IUGR) infants participated in this retrospective, observational study. RDW was measured before 3 days of life (T0) in all infants, and at first month of life (T1) in preterm/IURG patients.
Results
RDW% mean (standard deviation) at T0 was: 15.65 (1.18) in full-term newborns; 17.7 (2.06) in preterm; 17.45 (1.81) in IUGR. A negative correlation (r = −0.51; P < 0.001) between RDW and gestational age was found. RDW at T1 was: 17.25 (2.19) in the preterm group; 17.37 (2.56) in IUGR group. Fourteen preterm infants reported: 12 PDA, 5 LOS, 4 BPD, and 3 died; 10 IUGR infants had: 4 PDA, 6 LOS, 3 BPD, and 1 died.
RDW of IUGR infants suffering from those pathologies was not statistically different compared with unaffected infants, while preterm newborns with pathologies reported higher RDW: PDA vs. PDA absent: P = 0.008 at T0; P < 0.002 at T1. BPD vs. BPD absent: P < 0.005 at T1. LOS vs. LOS absent: P < 0.005 at T0.
RDW in preterm/IUGR population was associated with early mortality, T0: dead 21.2 (2.7) vs. alive 16.7 (1.7), P < 0.0001.
Conclusion
RDW and gestational age at birth were negatively correlated. High RDW resulted to be an indication of risk for critical newborns. This parameter can be inexpensively and routinely verified and further studies are required to confirm its prognostic role in neonatal pathologies.</description><identifier>ISSN: 1607-8454</identifier><identifier>EISSN: 1607-8454</identifier><identifier>DOI: 10.1179/1607845413Y.0000000141</identifier><identifier>PMID: 24225072</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Erythrocyte Indices ; Erythrocytes - pathology ; Female ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - pathology ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature - blood ; Male ; Mortality ; Neonatal pathologies ; Newborn infants ; RDW ; Retrospective Studies</subject><ispartof>Hematology (Luxembourg), 2014-09, Vol.19 (6), p.365-369</ispartof><rights>W. S. Maney & Son Ltd 2014 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f8655591088e0aeef02e623ce3a2468b23bb081fab17347cb0870cb0b61170793</citedby><cites>FETCH-LOGICAL-c417t-f8655591088e0aeef02e623ce3a2468b23bb081fab17347cb0870cb0b61170793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24225072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garofoli, Francesca</creatorcontrib><creatorcontrib>Ciardelli, Laura</creatorcontrib><creatorcontrib>Mazzucchelli, Iolanda</creatorcontrib><creatorcontrib>Borghesi, Alessandro</creatorcontrib><creatorcontrib>Angelini, Micol</creatorcontrib><creatorcontrib>Bollani, Lina</creatorcontrib><creatorcontrib>Genini, Emilia</creatorcontrib><creatorcontrib>Manzoni, Paolo</creatorcontrib><creatorcontrib>Paolillo, Piermichele</creatorcontrib><creatorcontrib>Tinelli, Carmine</creatorcontrib><creatorcontrib>Merlini, Giampaolo</creatorcontrib><creatorcontrib>Stronati, Mauro</creatorcontrib><title>The red cell distribution width (RDW): Value and role in preterm, IUGR (intrauterine growth restricted), full-term infants</title><title>Hematology (Luxembourg)</title><addtitle>Hematology</addtitle><description>Objective
To measure the red cell distribution width (RDW) ranges at birth and to evaluate potential association with typical neonatal diseases: patent of the ductus arteriousus (PDA), bronchopulmonary dysplasia (BPD), and late-onset sepsis (LOS) mortality.
Methods
Forty-six full-term, 41 preterm, and 35 intrauterine growth restricted (IUGR) infants participated in this retrospective, observational study. RDW was measured before 3 days of life (T0) in all infants, and at first month of life (T1) in preterm/IURG patients.
Results
RDW% mean (standard deviation) at T0 was: 15.65 (1.18) in full-term newborns; 17.7 (2.06) in preterm; 17.45 (1.81) in IUGR. A negative correlation (r = −0.51; P < 0.001) between RDW and gestational age was found. RDW at T1 was: 17.25 (2.19) in the preterm group; 17.37 (2.56) in IUGR group. Fourteen preterm infants reported: 12 PDA, 5 LOS, 4 BPD, and 3 died; 10 IUGR infants had: 4 PDA, 6 LOS, 3 BPD, and 1 died.
RDW of IUGR infants suffering from those pathologies was not statistically different compared with unaffected infants, while preterm newborns with pathologies reported higher RDW: PDA vs. PDA absent: P = 0.008 at T0; P < 0.002 at T1. BPD vs. BPD absent: P < 0.005 at T1. LOS vs. LOS absent: P < 0.005 at T0.
RDW in preterm/IUGR population was associated with early mortality, T0: dead 21.2 (2.7) vs. alive 16.7 (1.7), P < 0.0001.
Conclusion
RDW and gestational age at birth were negatively correlated. High RDW resulted to be an indication of risk for critical newborns. This parameter can be inexpensively and routinely verified and further studies are required to confirm its prognostic role in neonatal pathologies.</description><subject>Erythrocyte Indices</subject><subject>Erythrocytes - pathology</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - pathology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Male</subject><subject>Mortality</subject><subject>Neonatal pathologies</subject><subject>Newborn infants</subject><subject>RDW</subject><subject>Retrospective Studies</subject><issn>1607-8454</issn><issn>1607-8454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtOxCAQhonReH4Fw-WaWAV6oOudWY-JiYnxEK8IbaeKoWUdaDb69NKspzu5gIH5_xnmI2SPs0PO5fSIF0yWWZ7x9OmQLRfP-ArZHBPJmFn9E2-QLe9fGROCSbZONkQmRM6k2CQfdy9AERpag7W0MT6gqYZgXE8XpgkvdHJ7-rh_TB-0HYDqvqHoLFDT0zlCAOwO6NX9xS2dmD6gHuKL6YE-o1tEL8JYrg7Q7B_QdrA2GR3R3Oo--B2y1mrrYffr3Cb352d3s8vk-ubianZyndQZlyFpyyLP8ylnZQlMA7RMQCHSGlItsqKsRFpVrOStrrhMM1nHi2Rxr4oIislpuk0my7pzdG9D_JLqjB_H1T24wSueZ1MupShHabGU1ui8R2jVHE2n8V1xpkbu6g939cs9Gve-egxVB82P7Rt0FJwsBXF4h51eOLSNCvrdOmxR97XxKv2nySdluZEh</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Garofoli, Francesca</creator><creator>Ciardelli, Laura</creator><creator>Mazzucchelli, Iolanda</creator><creator>Borghesi, Alessandro</creator><creator>Angelini, Micol</creator><creator>Bollani, Lina</creator><creator>Genini, Emilia</creator><creator>Manzoni, Paolo</creator><creator>Paolillo, Piermichele</creator><creator>Tinelli, Carmine</creator><creator>Merlini, Giampaolo</creator><creator>Stronati, Mauro</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>The red cell distribution width (RDW): Value and role in preterm, IUGR (intrauterine growth restricted), full-term infants</title><author>Garofoli, Francesca ; Ciardelli, Laura ; Mazzucchelli, Iolanda ; Borghesi, Alessandro ; Angelini, Micol ; Bollani, Lina ; Genini, Emilia ; Manzoni, Paolo ; Paolillo, Piermichele ; Tinelli, Carmine ; Merlini, Giampaolo ; Stronati, Mauro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f8655591088e0aeef02e623ce3a2468b23bb081fab17347cb0870cb0b61170793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Erythrocyte Indices</topic><topic>Erythrocytes - pathology</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - pathology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Male</topic><topic>Mortality</topic><topic>Neonatal pathologies</topic><topic>Newborn infants</topic><topic>RDW</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garofoli, Francesca</creatorcontrib><creatorcontrib>Ciardelli, Laura</creatorcontrib><creatorcontrib>Mazzucchelli, Iolanda</creatorcontrib><creatorcontrib>Borghesi, Alessandro</creatorcontrib><creatorcontrib>Angelini, Micol</creatorcontrib><creatorcontrib>Bollani, Lina</creatorcontrib><creatorcontrib>Genini, Emilia</creatorcontrib><creatorcontrib>Manzoni, Paolo</creatorcontrib><creatorcontrib>Paolillo, Piermichele</creatorcontrib><creatorcontrib>Tinelli, Carmine</creatorcontrib><creatorcontrib>Merlini, Giampaolo</creatorcontrib><creatorcontrib>Stronati, Mauro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hematology (Luxembourg)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garofoli, Francesca</au><au>Ciardelli, Laura</au><au>Mazzucchelli, Iolanda</au><au>Borghesi, Alessandro</au><au>Angelini, Micol</au><au>Bollani, Lina</au><au>Genini, Emilia</au><au>Manzoni, Paolo</au><au>Paolillo, Piermichele</au><au>Tinelli, Carmine</au><au>Merlini, Giampaolo</au><au>Stronati, Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The red cell distribution width (RDW): Value and role in preterm, IUGR (intrauterine growth restricted), full-term infants</atitle><jtitle>Hematology (Luxembourg)</jtitle><addtitle>Hematology</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>19</volume><issue>6</issue><spage>365</spage><epage>369</epage><pages>365-369</pages><issn>1607-8454</issn><eissn>1607-8454</eissn><abstract>Objective
To measure the red cell distribution width (RDW) ranges at birth and to evaluate potential association with typical neonatal diseases: patent of the ductus arteriousus (PDA), bronchopulmonary dysplasia (BPD), and late-onset sepsis (LOS) mortality.
Methods
Forty-six full-term, 41 preterm, and 35 intrauterine growth restricted (IUGR) infants participated in this retrospective, observational study. RDW was measured before 3 days of life (T0) in all infants, and at first month of life (T1) in preterm/IURG patients.
Results
RDW% mean (standard deviation) at T0 was: 15.65 (1.18) in full-term newborns; 17.7 (2.06) in preterm; 17.45 (1.81) in IUGR. A negative correlation (r = −0.51; P < 0.001) between RDW and gestational age was found. RDW at T1 was: 17.25 (2.19) in the preterm group; 17.37 (2.56) in IUGR group. Fourteen preterm infants reported: 12 PDA, 5 LOS, 4 BPD, and 3 died; 10 IUGR infants had: 4 PDA, 6 LOS, 3 BPD, and 1 died.
RDW of IUGR infants suffering from those pathologies was not statistically different compared with unaffected infants, while preterm newborns with pathologies reported higher RDW: PDA vs. PDA absent: P = 0.008 at T0; P < 0.002 at T1. BPD vs. BPD absent: P < 0.005 at T1. LOS vs. LOS absent: P < 0.005 at T0.
RDW in preterm/IUGR population was associated with early mortality, T0: dead 21.2 (2.7) vs. alive 16.7 (1.7), P < 0.0001.
Conclusion
RDW and gestational age at birth were negatively correlated. High RDW resulted to be an indication of risk for critical newborns. This parameter can be inexpensively and routinely verified and further studies are required to confirm its prognostic role in neonatal pathologies.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>24225072</pmid><doi>10.1179/1607845413Y.0000000141</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Erythrocyte Indices Erythrocytes - pathology Female Fetal Growth Retardation - blood Fetal Growth Retardation - pathology Gestational Age Humans Infant, Newborn Infant, Premature - blood Male Mortality Neonatal pathologies Newborn infants RDW Retrospective Studies |
| title | The red cell distribution width (RDW): Value and role in preterm, IUGR (intrauterine growth restricted), full-term infants |
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