Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients

T-cell infiltration in estrogen receptor (ER)-negative breast tumours has been associated with longer survival. To investigate this association and the potential of tumour T-cell infiltration as a prognostic and predictive marker, we have conducted the largest study of T cells in breast cancer to da...

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Veröffentlicht in:	Annals of oncology 2014-08, Vol.25 (8), p.1536-1543
Hauptverfasser:	Ali, H.R., Provenzano, E., Dawson, S.-J., Blows, F.M., Liu, B., Shah, M., Earl, H.M., Poole, C.J., Hiller, L., Dunn, J.A., Bowden, S.J., Twelves, C., Bartlett, J.M.S., Mahmoud, S.M.A., Rakha, E., Ellis, I.O., Liu, S., Gao, D., Nielsen, T.O., Pharoah, P.D.P., Caldas, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Biomarkers, Tumor - metabolism breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - mortality Breast Neoplasms - pathology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology chemotherapy Female Gynecology. Andrology. Obstetrics Humans inflammation Lymphocyte Count lymphocytes Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Mammary gland diseases Medical sciences Middle Aged molecular subtypes Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Predictive Value of Tests Receptors, Progesterone - metabolism Survival Analysis Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - immunology Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - mortality Tumors
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