Cell-based screening assay for anti-inflammatory activity of bioactive compounds

•HEK293-NF-κB-luc2P cells are suitable for screening anti-inflammatory bioactives.•Minced broccoli seedlings and sulphoraphane show potent anti-inflammatory activity.•SCFA, especially butyrate, exert anti-inflammatory activity. Excess dietary intake may induce metabolic inflammation which is associa...

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Veröffentlicht in:	Food chemistry 2015-01, Vol.166, p.158-164
Hauptverfasser:	Meijer, Kees, Vonk, Roel J., Priebe, Marion G., Roelofsen, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory Anti-Inflammatory Agents - pharmacology Butyrate HEK293 HEK293 Cells Humans Inflammation - drug therapy Isothiocyanates - chemistry Lutein NF-kappa B - metabolism NF-κB Reporter assay SCFA Sulphoraphane Tumor Necrosis Factor-alpha - metabolism
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