Thirteen-week toxicity studies of 3,3′-dimethoxybenzidene and C.I. direct blue 15 in the fischer 344 rat

The benzidine congener 3,3′-dimethoxybenzidine (DMOB), and C.I. Direct Blue 15 (Blue 15), a prototypical compound of the DMOB-derived class of dyes, were evaluated in 13-week studies to characterize the toxicity and establish dose levels for subsequent chronic studies. Groups of 10 Fischer 344 rats...

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Veröffentlicht in:	Toxicology (Amsterdam) 1989-12, Vol.59 (3), p.297-309
Hauptverfasser:	Morgan, Daniel L., Jameson, C.W., Mennear, John H., Ulland, Borge M., Lemen, Joan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,3′-Dimethoxybenzidine Animals Azo Compounds - toxicity Benzidines - toxicity C.I. Direct Blue 15 Chemical Phenomena Chemistry Coloring Agents - toxicity Dianisidine - toxicity Dose-Response Relationship, Drug Drinking - drug effects Female Kidney - drug effects Liver - drug effects Male Nephropathy o-Dianisidine Organ Size - drug effects Rats Rats, Inbred F344 Thyroid Gland - drug effects Toxicity Weight Gain - drug effects
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