Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis

Liver fibrosis and its endstage, cirrhosis, represent a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) is a central event in hepatic fibrosis. However, the proteins that control HSC activation are incompletely understood. Here we show that (6aS, 10S, 11aR, 11bR, 1...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-08, Vol.60 (2), p.648-660
Hauptverfasser:	Xu, Wei‐Heng, Hu, Hong‐Gang, Tian, Yuan, Wang, Shao‐Zhan, Li, Jie, Li, Jian‐Zhong, Deng, Xing, Qian, Hui, Qiu, Lei, Hu, Zhen‐Lin, Wu, Qiu‐Ye, Chai, Yi‐Feng, Guo, Cheng, Xie, Wei‐Fen, Zhang, Jun‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Alkaloids - pharmacology Animals Bile Cell Line, Transformed Disease Models, Animal Gene Knockdown Techniques Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - pathology Hepatic Stellate Cells - physiology Hepatology Heterocyclic Compounds, 4 or More Rings - pharmacology Liver cirrhosis Liver Cirrhosis - drug therapy Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology Male Medicine, Chinese Traditional - methods Myofibroblasts - drug effects Myofibroblasts - pathology Myofibroblasts - physiology Phosphorylation Phosphorylation - drug effects Phosphorylation - physiology Primary Cell Culture Quinolizines - pharmacology Rats Rats, Sprague-Dawley Ribosomal Proteins - genetics Ribosomal Proteins - physiology Signal Transduction - drug effects Signal Transduction - physiology
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