Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell‐cycle control and apoptosis

The nuclear factor erythroid‐derived 2, like 2 (Nrf2) transcription factor is a key regulator of the antioxidant defense system, and pharmacological activation of Nrf2 is a promising strategy for prevention of toxin‐induced liver damage. However, the consequences of Nrf2 activation on liver regenera...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-08, Vol.60 (2), p.670-678
Hauptverfasser:	Köhler, Ulrike A., Kurinna, Svitlana, Schwitter, Dominik, Marti, Andrea, Schäfer, Matthias, Hellerbrand, Claus, Speicher, Tobias, Werner, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 Carbon Tetrachloride Poisoning - genetics Carbon Tetrachloride Poisoning - metabolism Cell Cycle - physiology Cell Proliferation Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Cyclin-Dependent Kinase Inhibitor p15 - metabolism Cyclin-dependent kinases Disease Models, Animal Hepatocytes - physiology Hepatology Homeostasis - physiology Insulin-Like Growth Factor I - metabolism Liver Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Regeneration - physiology Membrane Proteins - metabolism Mice Mice, Transgenic NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Proto-Oncogene Proteins - metabolism Receptor, Notch1 - metabolism Rodents
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