Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase

[Display omitted] •PDI was challenged with the bicarbonate-dependent peroxidase activity of hSOD1.•The challenge resulted in PDI oxidation, inactivation and covalent aggregation.•MS analysis of PDI radical adducts evidenced radicals on 3 tyrosine residues.•PDI was also oxidized, inactivated and aggr...

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