Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particular, it bound with high affinity (Ki < 1...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-09, Vol.350 (3), p.589-604
Hauptverfasser:	Maeda, Kenji, Sugino, Haruhiko, Akazawa, Hitomi, Amada, Naoki, Shimada, Jun, Futamura, Takashi, Yamashita, Hiroshi, Ito, Nobuaki, McQuade, Robert D., Mørk, Arne, Pehrson, Alan L., Hentzer, Morten, Nielsen, Vibeke, Bundgaard, Christoffer, Arnt, Jørn, Stensbøl, Tine Bryan, Kikuchi, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor CHO Cells Cricetinae Cricetulus Dopamine - metabolism Dopamine Agents - chemistry Dopamine Agents - metabolism Dopamine D2 Receptor Antagonists Dose-Response Relationship, Drug Humans Male Protein Binding - physiology Quinolones - chemistry Quinolones - metabolism Quinolones - pharmacology Rats Rats, Wistar Receptor, Serotonin, 5-HT1A - metabolism Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - metabolism Serotonin - metabolism Serotonin Agents - chemistry Serotonin Agents - metabolism Thiophenes - chemistry Thiophenes - metabolism Thiophenes - pharmacology
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