Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results
Purpose HistoScanning™ (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCa). The aim of this study was to evaluate the accuracy of total tumor volume measured by HS (TVHS) in patients with PCa. Methods In 148 patients with p...
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| Veröffentlicht in: | World journal of urology 2014-08, Vol.32 (4), p.939-944 |
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| creator | Schiffmann, J. Fischer, J. Tennstedt, P. Beyer, B. Böhm, K. Michl, U. Graefen, M. Salomon, G. |
| description | Purpose
HistoScanning™ (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCa). The aim of this study was to evaluate the accuracy of total tumor volume measured by HS (TVHS) in patients with PCa.
Methods
In 148 patients with proven PCa, TVHS was measured prior to radical prostatectomy and compared with the total tumor volume in the final pathological report (TVP) using the rank-based spearman correlation test. Correlation was performed after stratification of the results by d’Amico risk categories, prostate volume, experience of HS examiner, distance of the ultrasound probe to the prostate (≤3.5 and >3.5 mm) and quality of initial HS. In addition, a re-analysis of HS data was performed by a single examiner and the TVHS from the unmodified HS data was acquired.
Results
TVP was approximately twofold higher compared to TVHS. Overall, there was no significant correlation (
r
s
= −0.0083,
p
= 0.9) for the TVP and the TVHS. After adjusting for d’Amico risk categories, prostate volume, experience of examiner, distance of the ultrasound probe to the prostate and quality of initial HS, no significant correlation was found. After re-analyzing of all HS data by 1 examiner, the correlation remained not significant (
r
s
= 0.039,
p
= 0.6).
Conclusions
TVHS and TVP did not correlate in this cohort of patients. We cannot recommend the use of HS at least for imaging of the total tumor volume at this time. The controversial findings for prostate HS should initiate more studies to clarify these discrepancies. |
| doi_str_mv | 10.1007/s00345-013-1211-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1548192722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3380996791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-2857f5d9649f67d12ce7295748bad30ca7e63e51d33d1e99a05869545eefd7c3</originalsourceid><addsrcrecordid>eNp1kU1KBDEQhYMoOv4cwI0E3LhpzW-ns5RBHUFwofuQSarHlu7OmHQL7j2JR_MkZhwVEVwV1PvqFVUPoUNKTikh6iwRwoUsCOUFZZQWfANNqOC8qBQrN9GEKCYKoSu-g3ZTeiSEqpLIbbTDBFNEl9UEwTR0SxubFHocaryMIQ12AOxs7yDi59COHeAObBojeDx_wbMmDeEu633TL95f37DtPa6b3rb4YSUt7fAQ2rBoXO5ESGM7pH20Vds2wcFX3UP3lxf301lxc3t1PT2_KZwgcihYJVUtvS6FrkvlKXOgmJZKVHPrOXFWQclBUs-5p6C1JbIqtRQSoPbK8T10srbNZzyNkAbTNclB29oewpgMlaKiminGMnr8B30MY8xHfFJKEiW0zBRdUy7_JUWozTI2nY0vhhKzisCsIzA5ArOKwPA8c_TlPM478D8T3z_PAFsDKUv9AuKv1f-6fgA-t5K7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547507495</pqid></control><display><type>article</type><title>Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Schiffmann, J. ; Fischer, J. ; Tennstedt, P. ; Beyer, B. ; Böhm, K. ; Michl, U. ; Graefen, M. ; Salomon, G.</creator><creatorcontrib>Schiffmann, J. ; Fischer, J. ; Tennstedt, P. ; Beyer, B. ; Böhm, K. ; Michl, U. ; Graefen, M. ; Salomon, G.</creatorcontrib><description>Purpose
HistoScanning™ (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCa). The aim of this study was to evaluate the accuracy of total tumor volume measured by HS (TVHS) in patients with PCa.
Methods
In 148 patients with proven PCa, TVHS was measured prior to radical prostatectomy and compared with the total tumor volume in the final pathological report (TVP) using the rank-based spearman correlation test. Correlation was performed after stratification of the results by d’Amico risk categories, prostate volume, experience of HS examiner, distance of the ultrasound probe to the prostate (≤3.5 and >3.5 mm) and quality of initial HS. In addition, a re-analysis of HS data was performed by a single examiner and the TVHS from the unmodified HS data was acquired.
Results
TVP was approximately twofold higher compared to TVHS. Overall, there was no significant correlation (
r
s
= −0.0083,
p
= 0.9) for the TVP and the TVHS. After adjusting for d’Amico risk categories, prostate volume, experience of examiner, distance of the ultrasound probe to the prostate and quality of initial HS, no significant correlation was found. After re-analyzing of all HS data by 1 examiner, the correlation remained not significant (
r
s
= 0.039,
p
= 0.6).
Conclusions
TVHS and TVP did not correlate in this cohort of patients. We cannot recommend the use of HS at least for imaging of the total tumor volume at this time. The controversial findings for prostate HS should initiate more studies to clarify these discrepancies.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-013-1211-3</identifier><identifier>PMID: 24270968</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Cohort Studies ; Humans ; Image Processing, Computer-Assisted - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Oncology ; Organ Size ; Original Article ; Preoperative Care ; Prostate - diagnostic imaging ; Prostate - pathology ; Prostate - surgery ; Prostatectomy ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Retrospective Studies ; Sensitivity and Specificity ; Tumor Burden ; Ultrasonography - methods ; Urology</subject><ispartof>World journal of urology, 2014-08, Vol.32 (4), p.939-944</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-2857f5d9649f67d12ce7295748bad30ca7e63e51d33d1e99a05869545eefd7c3</citedby><cites>FETCH-LOGICAL-c405t-2857f5d9649f67d12ce7295748bad30ca7e63e51d33d1e99a05869545eefd7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-013-1211-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-013-1211-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24270968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiffmann, J.</creatorcontrib><creatorcontrib>Fischer, J.</creatorcontrib><creatorcontrib>Tennstedt, P.</creatorcontrib><creatorcontrib>Beyer, B.</creatorcontrib><creatorcontrib>Böhm, K.</creatorcontrib><creatorcontrib>Michl, U.</creatorcontrib><creatorcontrib>Graefen, M.</creatorcontrib><creatorcontrib>Salomon, G.</creatorcontrib><title>Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
HistoScanning™ (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCa). The aim of this study was to evaluate the accuracy of total tumor volume measured by HS (TVHS) in patients with PCa.
Methods
In 148 patients with proven PCa, TVHS was measured prior to radical prostatectomy and compared with the total tumor volume in the final pathological report (TVP) using the rank-based spearman correlation test. Correlation was performed after stratification of the results by d’Amico risk categories, prostate volume, experience of HS examiner, distance of the ultrasound probe to the prostate (≤3.5 and >3.5 mm) and quality of initial HS. In addition, a re-analysis of HS data was performed by a single examiner and the TVHS from the unmodified HS data was acquired.
Results
TVP was approximately twofold higher compared to TVHS. Overall, there was no significant correlation (
r
s
= −0.0083,
p
= 0.9) for the TVP and the TVHS. After adjusting for d’Amico risk categories, prostate volume, experience of examiner, distance of the ultrasound probe to the prostate and quality of initial HS, no significant correlation was found. After re-analyzing of all HS data by 1 examiner, the correlation remained not significant (
r
s
= 0.039,
p
= 0.6).
Conclusions
TVHS and TVP did not correlate in this cohort of patients. We cannot recommend the use of HS at least for imaging of the total tumor volume at this time. The controversial findings for prostate HS should initiate more studies to clarify these discrepancies.</description><subject>Aged</subject><subject>Cohort Studies</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Organ Size</subject><subject>Original Article</subject><subject>Preoperative Care</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostate - pathology</subject><subject>Prostate - surgery</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Tumor Burden</subject><subject>Ultrasonography - methods</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1KBDEQhYMoOv4cwI0E3LhpzW-ns5RBHUFwofuQSarHlu7OmHQL7j2JR_MkZhwVEVwV1PvqFVUPoUNKTikh6iwRwoUsCOUFZZQWfANNqOC8qBQrN9GEKCYKoSu-g3ZTeiSEqpLIbbTDBFNEl9UEwTR0SxubFHocaryMIQ12AOxs7yDi59COHeAObBojeDx_wbMmDeEu633TL95f37DtPa6b3rb4YSUt7fAQ2rBoXO5ESGM7pH20Vds2wcFX3UP3lxf301lxc3t1PT2_KZwgcihYJVUtvS6FrkvlKXOgmJZKVHPrOXFWQclBUs-5p6C1JbIqtRQSoPbK8T10srbNZzyNkAbTNclB29oewpgMlaKiminGMnr8B30MY8xHfFJKEiW0zBRdUy7_JUWozTI2nY0vhhKzisCsIzA5ArOKwPA8c_TlPM478D8T3z_PAFsDKUv9AuKv1f-6fgA-t5K7</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Schiffmann, J.</creator><creator>Fischer, J.</creator><creator>Tennstedt, P.</creator><creator>Beyer, B.</creator><creator>Böhm, K.</creator><creator>Michl, U.</creator><creator>Graefen, M.</creator><creator>Salomon, G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results</title><author>Schiffmann, J. ; Fischer, J. ; Tennstedt, P. ; Beyer, B. ; Böhm, K. ; Michl, U. ; Graefen, M. ; Salomon, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-2857f5d9649f67d12ce7295748bad30ca7e63e51d33d1e99a05869545eefd7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Cohort Studies</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Organ Size</topic><topic>Original Article</topic><topic>Preoperative Care</topic><topic>Prostate - diagnostic imaging</topic><topic>Prostate - pathology</topic><topic>Prostate - surgery</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Tumor Burden</topic><topic>Ultrasonography - methods</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiffmann, J.</creatorcontrib><creatorcontrib>Fischer, J.</creatorcontrib><creatorcontrib>Tennstedt, P.</creatorcontrib><creatorcontrib>Beyer, B.</creatorcontrib><creatorcontrib>Böhm, K.</creatorcontrib><creatorcontrib>Michl, U.</creatorcontrib><creatorcontrib>Graefen, M.</creatorcontrib><creatorcontrib>Salomon, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiffmann, J.</au><au>Fischer, J.</au><au>Tennstedt, P.</au><au>Beyer, B.</au><au>Böhm, K.</au><au>Michl, U.</au><au>Graefen, M.</au><au>Salomon, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>32</volume><issue>4</issue><spage>939</spage><epage>944</epage><pages>939-944</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose
HistoScanning™ (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCa). The aim of this study was to evaluate the accuracy of total tumor volume measured by HS (TVHS) in patients with PCa.
Methods
In 148 patients with proven PCa, TVHS was measured prior to radical prostatectomy and compared with the total tumor volume in the final pathological report (TVP) using the rank-based spearman correlation test. Correlation was performed after stratification of the results by d’Amico risk categories, prostate volume, experience of HS examiner, distance of the ultrasound probe to the prostate (≤3.5 and >3.5 mm) and quality of initial HS. In addition, a re-analysis of HS data was performed by a single examiner and the TVHS from the unmodified HS data was acquired.
Results
TVP was approximately twofold higher compared to TVHS. Overall, there was no significant correlation (
r
s
= −0.0083,
p
= 0.9) for the TVP and the TVHS. After adjusting for d’Amico risk categories, prostate volume, experience of examiner, distance of the ultrasound probe to the prostate and quality of initial HS, no significant correlation was found. After re-analyzing of all HS data by 1 examiner, the correlation remained not significant (
r
s
= 0.039,
p
= 0.6).
Conclusions
TVHS and TVP did not correlate in this cohort of patients. We cannot recommend the use of HS at least for imaging of the total tumor volume at this time. The controversial findings for prostate HS should initiate more studies to clarify these discrepancies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24270968</pmid><doi>10.1007/s00345-013-1211-3</doi><tpages>6</tpages></addata></record> |
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| issn | 0724-4983 1433-8726 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Cohort Studies Humans Image Processing, Computer-Assisted - methods Male Medicine Medicine & Public Health Middle Aged Nephrology Oncology Organ Size Original Article Preoperative Care Prostate - diagnostic imaging Prostate - pathology Prostate - surgery Prostatectomy Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Retrospective Studies Sensitivity and Specificity Tumor Burden Ultrasonography - methods Urology |
| title | Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results |
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