Restoring TGFβ1 pathway-related microRNAs: possible impact in metastatic prostate cancer development

In developed countries, prostate cancer (PC) is the neoplasia more frequently diagnosed in men. The signaling pathway induced by the transforming growth factor β1 (TGFβ1) has an important role in cell growth, differentiation, and development, the downregulation of this pathway being associated with...

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Veröffentlicht in:	Tumor biology 2014-07, Vol.35 (7), p.6245-6253
Hauptverfasser:	Santos, Juliana Inês, Teixeira, Ana Luísa, Dias, Francisca, Gomes, Mónica, Nogueira, Augusto, Assis, Joana, Medeiros, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Biomedical and Life Sciences Biomedicine Cancer Research Cell Differentiation - genetics Cell Proliferation Gene Expression Regulation, Neoplastic Humans Male MicroRNAs - genetics Neoplasm Metastasis Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Review Signal Transduction - genetics Smad Proteins - genetics Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - genetics
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