Induction of drug-metabolizing enzymes and toxicity of trans-stilbene oxide in rat liver and kidney

The effect of trans-stilbene oxide (TSO) on organ function and morphology and on drug-metabolizing enzymes was determined in male Sprague-Dawley rats. TSO (300 or 600 mg/kg) was administered i.p., once daily for 5 consecutive days. At a dose of 300 mg/kg, TSO did not alter body weight, but increased...

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Veröffentlicht in:	Toxicology (Amsterdam) 1981, Vol.22 (2), p.149-160
Hauptverfasser:	Kuo, Chao-Hen, Hook, Jerry B., Bernstein, Jay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Enzyme Induction - drug effects Epoxide Hydrolases - biosynthesis Glucuronosyltransferase - biosynthesis Glutathione Transferase - biosynthesis Kidney - drug effects Kidney - enzymology Liver - drug effects Liver - enzymology Male Rats Rats, Inbred Strains Stilbenes - toxicity
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