JMJD5 Regulates Cell Cycle and Pluripotency in Human Embryonic Stem Cells

In mammalian embryos, embryonic stem cells (ESCs) and induced pluripotent cells, a shortened G1 phase is correlated with the pluripotent state. To molecularly define this phase, we compared transcripts from the shortened G1 of human ESCs (hESCs) with those from the longer G1 of derived endoderm. We...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2014-08, Vol.32 (8), p.2098-2110
Hauptverfasser:	Zhu, Hui, Hu, Shijun, Baker, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western CDKN1A (p21) Cell cycle Cell Cycle - physiology Cell Differentiation - physiology Chromatin Immunoprecipitation Cyclin-Dependent Kinase Inhibitor p21 - metabolism Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Flow Cytometry G1 phase Histone Demethylases - metabolism Human embryonic stem cells Humans JMJD5 Medical research Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism RNA, Small Interfering Stem cells Transcriptome Transduction, Genetic
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