Repair of Refractory Wounds Through Grafting of Artificial Dermis and Autologous Epidermis Aided by Vacuum-Assisted Closure
Background This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds. Methods Patients with refractory wounds underwent debridement. Then the VAC device was used to cu...
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| Veröffentlicht in: | Aesthetic plastic surgery 2014-08, Vol.38 (4), p.727-732 |
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| creator | Zhang, Chenwei Liu, Dalie Liang, Zhi Liu, Fei Lin, Haibo Guo, Zhengdong |
| description | Background
This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds.
Methods
Patients with refractory wounds underwent debridement. Then the VAC device was used to culture wound granulation tissue. After the wound granulation tissue began to grow, artificial dermis was grafted on the wounds with VAC treatment. Then autologous epidermis was grafted on the artificial dermis to repair the wounds after survival of the artificial epidermis. The study mainly observed length of the hospital stay, survival of the artificial dermis, time required for culture of the granulation tissue using VAC before grafting of the artificial dermis, survival time of the artificial dermis, survival conditions of the autologous epidermis, influence on functions of a healed wound at a functional part, healing conditions of donor sites, and recurrence conditions of the wounds.
Results
Healing was successful for 22 patients (95.7%), but treatment failed for 1 child. The 22 patients were followed up for 6 to 24 months. According to follow-up findings, the skin grafts had good color and a soft texture. They were wear resistant and posed no influence on function. The appearance of the final results was the same as that of the full-thickness skin graft. Mild or no pigmentation and no scar formation occurred at the donor sites, and the wounds did not recur.
Conclusion
Vacuum-assisted closure combined with grafting of artificial dermis and autologous epidermis is an effective means for repairing refractory wounds and is worth clinical popularizing and application.
Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
. |
| doi_str_mv | 10.1007/s00266-014-0341-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1547833991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1547833991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-719c6de0b93ca6442ebd59714a9fff536b90745dd7cb06f9f24946b768c7de6a3</originalsourceid><addsrcrecordid>eNp1kU1rFTEUhoNY7LX6A9xIwI2baL4maZbDbW0LBaG06i5k8nGbMndyTSaLi3_eXKdKEbrKIec5b96cF4B3BH8iGMvPBWMqBMKEI8w4QewFWBHOKOooJy_BCjPBESXixzF4XcoDxoRKyV-BY8oVpop0K_Drxu9MzDAFeONDNnZOeQ-_pzq5Am_vc6qbe3iRTZjjtDlQfZ5jiDaaEZ75vI0FmsnBvs5pTJtUCzzfRbc0-lY4OOzhN2Nr3aK-lFjmdrUeU6nZvwFHwYzFv308T8Ddl_Pb9SW6_npxte6vkeW4m5Ekygrn8aCYNYJz6gfXKUm4USGEjolBYck756QdsAgqtN9xMUhxaqXzwrAT8HHR3eX0s_oy6-bO-nE0k2-ONem4PGVMKdLQD_-hD6nmqbn7Q1Eu2t4bRRbK5lRK9kHvctyavNcE60MyeklGt2T0IRnN2sz7R-U6bL37N_E3igbQBSitNW18fvL0s6q_AUUtmXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547246007</pqid></control><display><type>article</type><title>Repair of Refractory Wounds Through Grafting of Artificial Dermis and Autologous Epidermis Aided by Vacuum-Assisted Closure</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Zhang, Chenwei ; Liu, Dalie ; Liang, Zhi ; Liu, Fei ; Lin, Haibo ; Guo, Zhengdong</creator><creatorcontrib>Zhang, Chenwei ; Liu, Dalie ; Liang, Zhi ; Liu, Fei ; Lin, Haibo ; Guo, Zhengdong</creatorcontrib><description>Background
This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds.
Methods
Patients with refractory wounds underwent debridement. Then the VAC device was used to culture wound granulation tissue. After the wound granulation tissue began to grow, artificial dermis was grafted on the wounds with VAC treatment. Then autologous epidermis was grafted on the artificial dermis to repair the wounds after survival of the artificial epidermis. The study mainly observed length of the hospital stay, survival of the artificial dermis, time required for culture of the granulation tissue using VAC before grafting of the artificial dermis, survival time of the artificial dermis, survival conditions of the autologous epidermis, influence on functions of a healed wound at a functional part, healing conditions of donor sites, and recurrence conditions of the wounds.
Results
Healing was successful for 22 patients (95.7%), but treatment failed for 1 child. The 22 patients were followed up for 6 to 24 months. According to follow-up findings, the skin grafts had good color and a soft texture. They were wear resistant and posed no influence on function. The appearance of the final results was the same as that of the full-thickness skin graft. Mild or no pigmentation and no scar formation occurred at the donor sites, and the wounds did not recur.
Conclusion
Vacuum-assisted closure combined with grafting of artificial dermis and autologous epidermis is an effective means for repairing refractory wounds and is worth clinical popularizing and application.
Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><identifier>ISSN: 0364-216X</identifier><identifier>EISSN: 1432-5241</identifier><identifier>DOI: 10.1007/s00266-014-0341-3</identifier><identifier>PMID: 24902915</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Autografts ; Child ; Epidermis - transplantation ; Female ; Granulation Tissue - physiology ; Humans ; Length of Stay ; Male ; Medicine ; Medicine & Public Health ; Negative-Pressure Wound Therapy ; Original Article ; Otorhinolaryngology ; Plastic Surgery ; Skin Transplantation ; Skin, Artificial ; Soft Tissue Injuries - surgery ; Wound Healing ; Young Adult</subject><ispartof>Aesthetic plastic surgery, 2014-08, Vol.38 (4), p.727-732</ispartof><rights>Springer Science+Business Media New York and International Society of Aesthetic Plastic Surgery 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-719c6de0b93ca6442ebd59714a9fff536b90745dd7cb06f9f24946b768c7de6a3</citedby><cites>FETCH-LOGICAL-c405t-719c6de0b93ca6442ebd59714a9fff536b90745dd7cb06f9f24946b768c7de6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00266-014-0341-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00266-014-0341-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24902915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Chenwei</creatorcontrib><creatorcontrib>Liu, Dalie</creatorcontrib><creatorcontrib>Liang, Zhi</creatorcontrib><creatorcontrib>Liu, Fei</creatorcontrib><creatorcontrib>Lin, Haibo</creatorcontrib><creatorcontrib>Guo, Zhengdong</creatorcontrib><title>Repair of Refractory Wounds Through Grafting of Artificial Dermis and Autologous Epidermis Aided by Vacuum-Assisted Closure</title><title>Aesthetic plastic surgery</title><addtitle>Aesth Plast Surg</addtitle><addtitle>Aesthetic Plast Surg</addtitle><description>Background
This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds.
Methods
Patients with refractory wounds underwent debridement. Then the VAC device was used to culture wound granulation tissue. After the wound granulation tissue began to grow, artificial dermis was grafted on the wounds with VAC treatment. Then autologous epidermis was grafted on the artificial dermis to repair the wounds after survival of the artificial epidermis. The study mainly observed length of the hospital stay, survival of the artificial dermis, time required for culture of the granulation tissue using VAC before grafting of the artificial dermis, survival time of the artificial dermis, survival conditions of the autologous epidermis, influence on functions of a healed wound at a functional part, healing conditions of donor sites, and recurrence conditions of the wounds.
Results
Healing was successful for 22 patients (95.7%), but treatment failed for 1 child. The 22 patients were followed up for 6 to 24 months. According to follow-up findings, the skin grafts had good color and a soft texture. They were wear resistant and posed no influence on function. The appearance of the final results was the same as that of the full-thickness skin graft. Mild or no pigmentation and no scar formation occurred at the donor sites, and the wounds did not recur.
Conclusion
Vacuum-assisted closure combined with grafting of artificial dermis and autologous epidermis is an effective means for repairing refractory wounds and is worth clinical popularizing and application.
Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><subject>Adult</subject><subject>Autografts</subject><subject>Child</subject><subject>Epidermis - transplantation</subject><subject>Female</subject><subject>Granulation Tissue - physiology</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Negative-Pressure Wound Therapy</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Skin Transplantation</subject><subject>Skin, Artificial</subject><subject>Soft Tissue Injuries - surgery</subject><subject>Wound Healing</subject><subject>Young Adult</subject><issn>0364-216X</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1rFTEUhoNY7LX6A9xIwI2baL4maZbDbW0LBaG06i5k8nGbMndyTSaLi3_eXKdKEbrKIec5b96cF4B3BH8iGMvPBWMqBMKEI8w4QewFWBHOKOooJy_BCjPBESXixzF4XcoDxoRKyV-BY8oVpop0K_Drxu9MzDAFeONDNnZOeQ-_pzq5Am_vc6qbe3iRTZjjtDlQfZ5jiDaaEZ75vI0FmsnBvs5pTJtUCzzfRbc0-lY4OOzhN2Nr3aK-lFjmdrUeU6nZvwFHwYzFv308T8Ddl_Pb9SW6_npxte6vkeW4m5Ekygrn8aCYNYJz6gfXKUm4USGEjolBYck756QdsAgqtN9xMUhxaqXzwrAT8HHR3eX0s_oy6-bO-nE0k2-ONem4PGVMKdLQD_-hD6nmqbn7Q1Eu2t4bRRbK5lRK9kHvctyavNcE60MyeklGt2T0IRnN2sz7R-U6bL37N_E3igbQBSitNW18fvL0s6q_AUUtmXA</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Zhang, Chenwei</creator><creator>Liu, Dalie</creator><creator>Liang, Zhi</creator><creator>Liu, Fei</creator><creator>Lin, Haibo</creator><creator>Guo, Zhengdong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Repair of Refractory Wounds Through Grafting of Artificial Dermis and Autologous Epidermis Aided by Vacuum-Assisted Closure</title><author>Zhang, Chenwei ; Liu, Dalie ; Liang, Zhi ; Liu, Fei ; Lin, Haibo ; Guo, Zhengdong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-719c6de0b93ca6442ebd59714a9fff536b90745dd7cb06f9f24946b768c7de6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Autografts</topic><topic>Child</topic><topic>Epidermis - transplantation</topic><topic>Female</topic><topic>Granulation Tissue - physiology</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Negative-Pressure Wound Therapy</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Skin Transplantation</topic><topic>Skin, Artificial</topic><topic>Soft Tissue Injuries - surgery</topic><topic>Wound Healing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Chenwei</creatorcontrib><creatorcontrib>Liu, Dalie</creatorcontrib><creatorcontrib>Liang, Zhi</creatorcontrib><creatorcontrib>Liu, Fei</creatorcontrib><creatorcontrib>Lin, Haibo</creatorcontrib><creatorcontrib>Guo, Zhengdong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Chenwei</au><au>Liu, Dalie</au><au>Liang, Zhi</au><au>Liu, Fei</au><au>Lin, Haibo</au><au>Guo, Zhengdong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repair of Refractory Wounds Through Grafting of Artificial Dermis and Autologous Epidermis Aided by Vacuum-Assisted Closure</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><addtitle>Aesthetic Plast Surg</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>38</volume><issue>4</issue><spage>727</spage><epage>732</epage><pages>727-732</pages><issn>0364-216X</issn><eissn>1432-5241</eissn><abstract>Background
This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds.
Methods
Patients with refractory wounds underwent debridement. Then the VAC device was used to culture wound granulation tissue. After the wound granulation tissue began to grow, artificial dermis was grafted on the wounds with VAC treatment. Then autologous epidermis was grafted on the artificial dermis to repair the wounds after survival of the artificial epidermis. The study mainly observed length of the hospital stay, survival of the artificial dermis, time required for culture of the granulation tissue using VAC before grafting of the artificial dermis, survival time of the artificial dermis, survival conditions of the autologous epidermis, influence on functions of a healed wound at a functional part, healing conditions of donor sites, and recurrence conditions of the wounds.
Results
Healing was successful for 22 patients (95.7%), but treatment failed for 1 child. The 22 patients were followed up for 6 to 24 months. According to follow-up findings, the skin grafts had good color and a soft texture. They were wear resistant and posed no influence on function. The appearance of the final results was the same as that of the full-thickness skin graft. Mild or no pigmentation and no scar formation occurred at the donor sites, and the wounds did not recur.
Conclusion
Vacuum-assisted closure combined with grafting of artificial dermis and autologous epidermis is an effective means for repairing refractory wounds and is worth clinical popularizing and application.
Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24902915</pmid><doi>10.1007/s00266-014-0341-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Aesthetic plastic surgery, 2014-08, Vol.38 (4), p.727-732 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Autografts Child Epidermis - transplantation Female Granulation Tissue - physiology Humans Length of Stay Male Medicine Medicine & Public Health Negative-Pressure Wound Therapy Original Article Otorhinolaryngology Plastic Surgery Skin Transplantation Skin, Artificial Soft Tissue Injuries - surgery Wound Healing Young Adult |
| title | Repair of Refractory Wounds Through Grafting of Artificial Dermis and Autologous Epidermis Aided by Vacuum-Assisted Closure |
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