microRNA-124 inhibits proliferation and induces apoptosis by directly repressing EZH2 in gastric cancer

MicroRNA-124 (miR-124), a pivotal member of the p53 network, was found to be down-regulated in multiple types of tumors and further reported as tumor suppressor microRNA. In this study, we found that miR-124 was down-regulated in gastric cancer cell lines and specimens. Restoration of miR-124 expres...

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Veröffentlicht in:	Molecular and cellular biochemistry 2014-07, Vol.392 (1-2), p.153-159
Hauptverfasser:	Xie, Liming, Zhang, Zhiwei, Tan, Zhiqin, He, Rongfang, Zeng, Xi, Xie, Yuanjie, Li, Suyun, Tang, Guohua, Tang, Hailin, He, Xiusheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cancer Cardiology Cell Line, Tumor Cell Proliferation Cellular biology Enhancer of Zeste Homolog 2 Protein Gastric cancer Gene Knockdown Techniques Gene therapy Genes Health aspects Humans Life Sciences Male Medical Biochemistry Mice Mice, Inbred BALB C MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - physiology Oncology Polycomb Repressive Complex 2 - genetics Stomach cancer Stomach Neoplasms - pathology Tumor proteins Tumors Up-Regulation
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