Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women: Improvements in Bone Geometry, Microarchitecture, and Estimated Bone Strength

ABSTRACT The cathepsin K inhibitor odanacatib (ODN), currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining bone formation. In phase 2 studies, odanacatib increased areal bone mineral density (aBMD) at the lumb...

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Veröffentlicht in:	Journal of bone and mineral research 2014-08, Vol.29 (8), p.1786-1794
Hauptverfasser:	Cheung, Angela M, Majumdar, Sharmila, Brixen, Kim, Chapurlat, Roland, Fuerst, Thomas, Engelke, Klaus, Dardzinski, Bernard, Cabal, Antonio, Verbruggen, Nadia, Ather, Shabana, Rosenberg, Elizabeth, de Papp, Anne E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biphenyl Compounds - pharmacology Bone and Bones - drug effects Bone and Bones - ultrastructure Bone Remodeling - drug effects Compressive Strength Female Humans Middle Aged ODANACATIB OSTEOPOROSIS Radius - drug effects Reference Standards Tibia - drug effects VOLUMETRIC BMD
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