Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway

Human acidic and basic fibroblast growth factors (aFGF and bFGF) inhibit epidermal growth factor (EGF) receptor binding in mouse Swiss 3T3 cells. Scatchard analysis indicates that aFGF and bFGF cause a decrease in the high affinity EGF receptor population, similar to that observed for activators of...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-10, Vol.164 (2), p.796-803
Hauptverfasser:	Hicks, Karen, Friedman, BethAnn, Rosner, Marsha Rich
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Bombesin - pharmacology Cattle Cells, Cultured Epidermal Growth Factor - metabolism ErbB Receptors - drug effects ErbB Receptors - metabolism Fibroblast Growth Factors - pharmacology Fundamental and applied biological sciences. Psychology Humans Kinetics Mice Pertussis Toxin Phorbol 12,13-Dibutyrate - pharmacology Platelet-Derived Growth Factor - pharmacology Protein hormones. Growth factors. Cytokines Protein Kinase C - metabolism Proteins Virulence Factors, Bordetella - pharmacology
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