Diazepam-insensitive ( super(3)H)Ro 15-4513 binding in intact cultured cerebellar granule cells

Diazepam-insensitive ( super(3)H)Ro 15-4513 binding in intact cultured cerebellar granule cells

( super(3)H)Ro 15-4513, a partial inverse agonist at the benzodiazepine receptor, binds to two sites in the rat cerebellum, only one of which is sensitive to diazepam. The diazepam-insensitive component, whose identity is unknown, is unique to this brain area. The authors studied the binding of ( su...

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Veröffentlicht in:European journal of pharmacology 1989-01, Vol.169 (1), p.53-60
Hauptverfasser: Malminiemi, O, Korpi, E R
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Korpi, E R
description ( super(3)H)Ro 15-4513, a partial inverse agonist at the benzodiazepine receptor, binds to two sites in the rat cerebellum, only one of which is sensitive to diazepam. The diazepam-insensitive component, whose identity is unknown, is unique to this brain area. The authors studied the binding of ( super(3)H)Ro 15-4513 in cultured cerebellar granule cells to characterize its binding sites in a specified neuronal cell population and to determine the effects of ethanol on the binding. The diazepam-insensitive ( super(3)H)Ro 15-4513 binding site may be associated with both GABA sub(A) and benzodiazepine receptors in the cerebellar granule cells. Its physiological role as a possible mediator of the actions of benzodiazepine inverse agonists remains to be studied.
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title Diazepam-insensitive ( super(3)H)Ro 15-4513 binding in intact cultured cerebellar granule cells
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