Paraganglionic cell response to chronic imipramine and handling stress: an ultrastructural study
The ultrastructure and connectivity of monoamine-storing paraganglionic cells in the rat superior cervical ganglion were investigated following chronic treatment with imipramine (Tofranil, Ciba-Geigy) and compared with uninjected unhandled controls and saline injected animals. The study reveals a si...
Gespeichert in:
| Veröffentlicht in: | Journal of Neural Transmission 1990-01, Vol.79 (3), p.169-181 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 3 |
| container_start_page | 169 |
| container_title | Journal of Neural Transmission |
| container_volume | 79 |
| creator | FOLAN, J. C JOHANSSON, O HEYM, C |
| description | The ultrastructure and connectivity of monoamine-storing paraganglionic cells in the rat superior cervical ganglion were investigated following chronic treatment with imipramine (Tofranil, Ciba-Geigy) and compared with uninjected unhandled controls and saline injected animals. The study reveals a significant decrease in the number of dense core vesicles in the drug-treated group (P less than 0.001) which is regarded as a specific effect due to receptor blocking actions of imipramine. A significant reduction in the maximum diameter of the external rim and internal cores of the vesicles (P less than 0.05) in the drug-treated group is mimicked to a certain extent by saline injections, indicating a mixed effect of stress handling and specific alteration. Although the paraganglionic cell morphology is unaltered in the group comparisons, the interrelationship of the paraganglionic cells to surrounding neural processes is significantly altered in both the control versus saline and the control versus drug group comparisons (P less than 0.05). The drug- and saline-induced alterations of neural connectivity may reflect stress-induced general changes demonstrating the plasticity of the paraganglionic cell population. |
| doi_str_mv | 10.1007/BF01245128 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15476673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15476673</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-c8be8a7e00e493de496b6f6027d82cf9b6e480af93e278a0f5ae716e313128c33</originalsourceid><addsrcrecordid>eNpFkDFPwzAQhS0EKqWwsCNlQAxIgXPs2AkbVBSQKsEAc7g4TmvkJMVOhv57XIjKcqe79-lJ7xFyTuGGAsjbhwXQhKc0yQ7IlHKWxpQLdkimwADiPBX8mJx4_wUAlMpsQiZJkksOdEo-39DhCtuVNV1rVKS0tZHTftO1Xkd9F6m1-xVMYzYOG9PqCNsqWodhTbuKfB9ofxee0WB7h-EeVD84tEEaqu0pOarRen027hn5WDy-z5_j5evTy_x-GStGaR-rrNQZSg2gec6qMEQpagGJrLJE1XkpNM8A65zpRGYIdYpaUqEZZSG2YmxGrv58N677HrTvi8b4XRpsdTf4gqZcCiF34PUfqFznvdN1sXGmQbctKBS7Oov_OgN8MboOZaOrPTr2F_TLUUev0NYOW2X8HhOCA6cZ-wGg3309</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15476673</pqid></control><display><type>article</type><title>Paraganglionic cell response to chronic imipramine and handling stress: an ultrastructural study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>FOLAN, J. C ; JOHANSSON, O ; HEYM, C</creator><creatorcontrib>FOLAN, J. C ; JOHANSSON, O ; HEYM, C</creatorcontrib><description>The ultrastructure and connectivity of monoamine-storing paraganglionic cells in the rat superior cervical ganglion were investigated following chronic treatment with imipramine (Tofranil, Ciba-Geigy) and compared with uninjected unhandled controls and saline injected animals. The study reveals a significant decrease in the number of dense core vesicles in the drug-treated group (P less than 0.001) which is regarded as a specific effect due to receptor blocking actions of imipramine. A significant reduction in the maximum diameter of the external rim and internal cores of the vesicles (P less than 0.05) in the drug-treated group is mimicked to a certain extent by saline injections, indicating a mixed effect of stress handling and specific alteration. Although the paraganglionic cell morphology is unaltered in the group comparisons, the interrelationship of the paraganglionic cells to surrounding neural processes is significantly altered in both the control versus saline and the control versus drug group comparisons (P less than 0.05). The drug- and saline-induced alterations of neural connectivity may reflect stress-induced general changes demonstrating the plasticity of the paraganglionic cell population.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF01245128</identifier><identifier>PMID: 2297401</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cytoplasmic Granules - ultrastructure ; Ganglia, Sympathetic - drug effects ; Ganglia, Sympathetic - physiopathology ; Ganglia, Sympathetic - ultrastructure ; Imipramine - pharmacology ; Male ; Medical sciences ; Microscopy, Electron ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Restraint, Physical ; Stress, Psychological - pathology ; Stress, Psychological - physiopathology</subject><ispartof>Journal of Neural Transmission, 1990-01, Vol.79 (3), p.169-181</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-c8be8a7e00e493de496b6f6027d82cf9b6e480af93e278a0f5ae716e313128c33</citedby><cites>FETCH-LOGICAL-c311t-c8be8a7e00e493de496b6f6027d82cf9b6e480af93e278a0f5ae716e313128c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6640418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2297401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOLAN, J. C</creatorcontrib><creatorcontrib>JOHANSSON, O</creatorcontrib><creatorcontrib>HEYM, C</creatorcontrib><title>Paraganglionic cell response to chronic imipramine and handling stress: an ultrastructural study</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm Gen Sect</addtitle><description>The ultrastructure and connectivity of monoamine-storing paraganglionic cells in the rat superior cervical ganglion were investigated following chronic treatment with imipramine (Tofranil, Ciba-Geigy) and compared with uninjected unhandled controls and saline injected animals. The study reveals a significant decrease in the number of dense core vesicles in the drug-treated group (P less than 0.001) which is regarded as a specific effect due to receptor blocking actions of imipramine. A significant reduction in the maximum diameter of the external rim and internal cores of the vesicles (P less than 0.05) in the drug-treated group is mimicked to a certain extent by saline injections, indicating a mixed effect of stress handling and specific alteration. Although the paraganglionic cell morphology is unaltered in the group comparisons, the interrelationship of the paraganglionic cells to surrounding neural processes is significantly altered in both the control versus saline and the control versus drug group comparisons (P less than 0.05). The drug- and saline-induced alterations of neural connectivity may reflect stress-induced general changes demonstrating the plasticity of the paraganglionic cell population.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>Ganglia, Sympathetic - drug effects</subject><subject>Ganglia, Sympathetic - physiopathology</subject><subject>Ganglia, Sympathetic - ultrastructure</subject><subject>Imipramine - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Restraint, Physical</subject><subject>Stress, Psychological - pathology</subject><subject>Stress, Psychological - physiopathology</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAQhS0EKqWwsCNlQAxIgXPs2AkbVBSQKsEAc7g4TmvkJMVOhv57XIjKcqe79-lJ7xFyTuGGAsjbhwXQhKc0yQ7IlHKWxpQLdkimwADiPBX8mJx4_wUAlMpsQiZJkksOdEo-39DhCtuVNV1rVKS0tZHTftO1Xkd9F6m1-xVMYzYOG9PqCNsqWodhTbuKfB9ofxee0WB7h-EeVD84tEEaqu0pOarRen027hn5WDy-z5_j5evTy_x-GStGaR-rrNQZSg2gec6qMEQpagGJrLJE1XkpNM8A65zpRGYIdYpaUqEZZSG2YmxGrv58N677HrTvi8b4XRpsdTf4gqZcCiF34PUfqFznvdN1sXGmQbctKBS7Oov_OgN8MboOZaOrPTr2F_TLUUev0NYOW2X8HhOCA6cZ-wGg3309</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>FOLAN, J. C</creator><creator>JOHANSSON, O</creator><creator>HEYM, C</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19900101</creationdate><title>Paraganglionic cell response to chronic imipramine and handling stress: an ultrastructural study</title><author>FOLAN, J. C ; JOHANSSON, O ; HEYM, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-c8be8a7e00e493de496b6f6027d82cf9b6e480af93e278a0f5ae716e313128c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>Ganglia, Sympathetic - drug effects</topic><topic>Ganglia, Sympathetic - physiopathology</topic><topic>Ganglia, Sympathetic - ultrastructure</topic><topic>Imipramine - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Restraint, Physical</topic><topic>Stress, Psychological - pathology</topic><topic>Stress, Psychological - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOLAN, J. C</creatorcontrib><creatorcontrib>JOHANSSON, O</creatorcontrib><creatorcontrib>HEYM, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOLAN, J. C</au><au>JOHANSSON, O</au><au>HEYM, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraganglionic cell response to chronic imipramine and handling stress: an ultrastructural study</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm Gen Sect</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>79</volume><issue>3</issue><spage>169</spage><epage>181</epage><pages>169-181</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>The ultrastructure and connectivity of monoamine-storing paraganglionic cells in the rat superior cervical ganglion were investigated following chronic treatment with imipramine (Tofranil, Ciba-Geigy) and compared with uninjected unhandled controls and saline injected animals. The study reveals a significant decrease in the number of dense core vesicles in the drug-treated group (P less than 0.001) which is regarded as a specific effect due to receptor blocking actions of imipramine. A significant reduction in the maximum diameter of the external rim and internal cores of the vesicles (P less than 0.05) in the drug-treated group is mimicked to a certain extent by saline injections, indicating a mixed effect of stress handling and specific alteration. Although the paraganglionic cell morphology is unaltered in the group comparisons, the interrelationship of the paraganglionic cells to surrounding neural processes is significantly altered in both the control versus saline and the control versus drug group comparisons (P less than 0.05). The drug- and saline-induced alterations of neural connectivity may reflect stress-induced general changes demonstrating the plasticity of the paraganglionic cell population.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>2297401</pmid><doi>10.1007/BF01245128</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9564 |
| ispartof | Journal of Neural Transmission, 1990-01, Vol.79 (3), p.169-181 |
| issn | 0300-9564 1435-1463 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15476673 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Cytoplasmic Granules - ultrastructure Ganglia, Sympathetic - drug effects Ganglia, Sympathetic - physiopathology Ganglia, Sympathetic - ultrastructure Imipramine - pharmacology Male Medical sciences Microscopy, Electron Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Restraint, Physical Stress, Psychological - pathology Stress, Psychological - physiopathology |
| title | Paraganglionic cell response to chronic imipramine and handling stress: an ultrastructural study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T10%3A00%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paraganglionic%20cell%20response%20to%20chronic%20imipramine%20and%20handling%20stress:%20an%20ultrastructural%20study&rft.jtitle=Journal%20of%20Neural%20Transmission&rft.au=FOLAN,%20J.%20C&rft.date=1990-01-01&rft.volume=79&rft.issue=3&rft.spage=169&rft.epage=181&rft.pages=169-181&rft.issn=0300-9564&rft.eissn=1435-1463&rft.coden=JNTMAH&rft_id=info:doi/10.1007/BF01245128&rft_dat=%3Cproquest_cross%3E15476673%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15476673&rft_id=info:pmid/2297401&rfr_iscdi=true |