Long-Term Transplantation of Canine Keratinocytes Made Resistant to G418 Through Retrovirus-Mediated Gene Transfer

We studied cultured canine keratinocytes to determine whether they could serve as targets for retrovirus-mediated gene transfer and whether infected cells could persist after transplantation into dogs, a large random-bred model for gene transfer studies. Canine keratinocytes obtained from skin biops...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-03, Vol.87 (6), p.2349-2353
Hauptverfasser:	Mary E. D. Flowers, Marcus A. R. Stockschlaeder, Schuening, Friedrich G., Niederwieser, Dietger, Hackman, Robert, Miller, A. Dusty, Storb, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Biopsies Biopsy Canines Cell Line Cells, Cultured cloning vectors Cultured cells Dogs Drug Resistance - genetics Feeder cells Female Fibroblasts gene transfer Genetic Vectors Gentamicins - pharmacology Keratinocytes Keratinocytes - drug effects Keratinocytes - transplantation Keratinocytes - ultrastructure Male Microscopy, Electron Retroviral vectors Retroviridae - genetics Skin Skin - cytology Skin - ultrastructure Transplantation Viruses
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