Müller glial cells inhibit proliferation of retinal endothelial cells via TGF-β2 and Smad signaling

Neovascularization is a sight‐threatening complication of ischemic proliferative retinopathies. Transforming growth factor (TGF)‐β, a cytokine with multiple functions in the retina, participates in the control of pathological angiogenesis and neovascularization. Retinal glial (Müller) cells produce...

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Veröffentlicht in:	Glia 2014-09, Vol.62 (9), p.1476-1485
Hauptverfasser:	Yafai, Yousef, Iandiev, Ianors, Lange, Johannes, Unterlauft, Jan Darius, Wiedemann, Peter, Bringmann, Andreas, Reichenbach, Andreas, Eichler, Wolfram
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Cattle Cell Hypoxia - physiology Cell Proliferation - physiology Cells, Cultured Coculture Techniques Endothelial Cells - physiology Ependymoglial Cells - physiology Guinea Pigs Humans MAP Kinase Signaling System - physiology Müller cell neovascularization Phosphorylation Rats, Long-Evans Recombinant Proteins - metabolism retina Retina - physiology Smad Proteins - metabolism Transforming Growth Factor beta2 - metabolism Vascular Endothelial Growth Factor A - metabolism
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