Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution

[Display omitted] The effects of drug-crystallization inhibitor in bile acid/lipid micelles solution on drug permeation was evaluated during the drug crystallization process. Hydroxypropyl methylcellulose acetate succinate (HPMC-AS) was used as a drug-crystallization inhibitor, which efficiently sup...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2014-10, Vol.62, p.293-300
Hauptverfasser:	Ueda, Keisuke, Higashi, Kenjirou, Kataoka, Makoto, Yamashita, Shinji, Yamamoto, Keiji, Moribe, Kunikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Caco-2 monolayer Crystallization Crystallization inhibition Dexamethasone - chemistry Dexamethasone - metabolism Dissolution/permeation system HPMC-AS Humans Intestinal Secretions - chemistry Methylcellulose - analogs & derivatives Methylcellulose - chemistry Permeability Solutions Supersaturated solution
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