Seven New Sesquiterpenoids from the Fruits of Schisandra sphenanthera

Seven New Sesquiterpenoids from the Fruits of Schisandra sphenanthera

Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1–7, in addition to the known metabolites 8–23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetrali...

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Veröffentlicht in:Chemistry & biodiversity 2014-07, Vol.11 (7), p.1053-1068
Hauptverfasser: Tsai, Yao-Ching, Cheng, Yuan-Bin, Lo, I-Wen, Cheng, Ho-Hsi, Lin, Ching-Jie, Hwang, Tsong-Long, Kuo, Yuh-Chi, Liou, Shorong-Shii, Huang, Yi-Zsau, Kuo, Yao-Haur, Shen, Ya-Ching
Format: Artikel
Sprache:eng
Schlagworte:
Anti-HSV-1 activity
Anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Fruit - chemistry
Herpes Simplex - drug therapy
Herpesvirus 1, Human - drug effects
Humans
Models, Molecular
Neutrophils - drug effects
Neutrophils - immunology
Schisandra - chemistry
Schisandra sphenanthera
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenoids
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Zusammenfassung:Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1–7, in addition to the known metabolites 8–23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti‐HSV‐1 and anti‐inflammatory activities. The results revealed that compound 4 exhibited anti‐HSV‐1 activity, while compound 6 showed a significant anti‐inflammatory activity.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201300259