Sensitive LC-MS/MS-ESI method for simultaneous determination of montelukast and fexofenadine in human plasma: application to a bioequivalence study

ABSTRACT A rapid, simple, sensitive and selective LC‐MS/MS method was developed and validated for simultaneous quantification of montelukast (MT) and fexofenadine (FF) in human plasma (200 μL) using montelukast‐d6 (MT‐d6) and fexofenadine‐d10 (FF‐d10), respectively as an internal standard (IS) as pe...

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Veröffentlicht in:	Biomedical chromatography 2014-08, Vol.28 (8), p.1048-1056
Hauptverfasser:	Muppavarapu, Rajendraprasad, Guttikar, Swati, Rajappan, Manavalan, Kamarajan, Kannan, Mullangi, Ramesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - blood Acetates - chemistry Acetates - pharmacokinetics Adult bioequivalence Chromatography, High Pressure Liquid - methods Cross-Over Studies Drug Stability fexofenadine human plasma Humans LC-MS/MS Linear Models Male method validation montelukast pharmacokinetics Quinolines - blood Quinolines - chemistry Quinolines - pharmacokinetics Reproducibility of Results Sensitivity and Specificity Single-Blind Method Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Terfenadine - analogs & derivatives Terfenadine - blood Terfenadine - chemistry Terfenadine - pharmacokinetics Therapeutic Equivalency
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