Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta-analysis
Background and Objective The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta‐analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastr...
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| Veröffentlicht in: | Journal of surgical oncology 2014-08, Vol.110 (2), p.129-135 |
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| creator | Choi, Yoon Young Bae, Jung Min An, Ji Yeong Kwon, In Gyu Cho, In Shin, Hyun Beak Eiji, Tanaka Aburahmah, Mohammad Kim, Hyung-Il Cheong, Jae-Ho Hyung, Woo Jin Noh, Sung Hoon |
| description | Background and Objective
The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta‐analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer.
Methods
A comprehensive systematic review and meta‐analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to “microsatellite instability,” “gastric cancer,” and “prognosis.”
Results
Twenty‐four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non‐MSI was 0.72 (95%CI: 0.59–0.88, P = .001) in a random‐effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity.
Conclusion
MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies. J. Surg. Oncol. 2014; 110:129–135. © 2014 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.23618 |
| format | Article |
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The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta‐analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer.
Methods
A comprehensive systematic review and meta‐analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to “microsatellite instability,” “gastric cancer,” and “prognosis.”
Results
Twenty‐four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non‐MSI was 0.72 (95%CI: 0.59–0.88, P = .001) in a random‐effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity.
Conclusion
MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies. J. Surg. Oncol. 2014; 110:129–135. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23618</identifier><identifier>PMID: 24737677</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - mortality ; gastric cancer ; Genetic Markers ; Humans ; Microsatellite Instability ; Models, Statistical ; MSI ; Prognosis ; Stomach Neoplasms - genetics ; Stomach Neoplasms - mortality ; Survival Analysis</subject><ispartof>Journal of surgical oncology, 2014-08, Vol.110 (2), p.129-135</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-dca2a70e238ab5ce9d7e628eb91e92c5abb11667f6a24184593aef1aa8ece2e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23618$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23618$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24737677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Yoon Young</creatorcontrib><creatorcontrib>Bae, Jung Min</creatorcontrib><creatorcontrib>An, Ji Yeong</creatorcontrib><creatorcontrib>Kwon, In Gyu</creatorcontrib><creatorcontrib>Cho, In</creatorcontrib><creatorcontrib>Shin, Hyun Beak</creatorcontrib><creatorcontrib>Eiji, Tanaka</creatorcontrib><creatorcontrib>Aburahmah, Mohammad</creatorcontrib><creatorcontrib>Kim, Hyung-Il</creatorcontrib><creatorcontrib>Cheong, Jae-Ho</creatorcontrib><creatorcontrib>Hyung, Woo Jin</creatorcontrib><creatorcontrib>Noh, Sung Hoon</creatorcontrib><title>Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta-analysis</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objective
The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta‐analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer.
Methods
A comprehensive systematic review and meta‐analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to “microsatellite instability,” “gastric cancer,” and “prognosis.”
Results
Twenty‐four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non‐MSI was 0.72 (95%CI: 0.59–0.88, P = .001) in a random‐effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity.
Conclusion
MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies. J. Surg. Oncol. 2014; 110:129–135. © 2014 Wiley Periodicals, Inc.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - mortality</subject><subject>gastric cancer</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Microsatellite Instability</subject><subject>Models, Statistical</subject><subject>MSI</subject><subject>Prognosis</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - mortality</subject><subject>Survival Analysis</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9PGzEQxS1UBIFy4AtUlnrhsmB7vfa6lwqhQkEIDgFxtGadCTjdP2A7pPvtcQjl0JNHfr83mnlDyCFnx5wxcbKIw7EoFa-3yIQzowrDTP2FTLImCqkN2yV7MS4YY8YouUN2hdSlVlpPSHsZaeddGCIkbFufkPo-Jmh8rkcK9DkMj_0Qk3e0g_AHQ9bpI8QU8o-D3mH4-YOe0jjGhB2suYCvHld05dMT7TBBAT20Y_TxK9meQxvx4OPdJ_fnv-7OfhfXtxeXZ6fXhZNC18XMgQDNUJQ1NJVDM9OoRI2N4WiEq6BpOFdKzxUIyWtZmRJwzgFqdChQlvvkaNM3D_-yxJhs56PL60GPwzJaXkldSVEKndHv_6GLYRnyvGuqKrlUmq8bfvuglk2HM_scfA5jtP9yzMDJBlj5FsdPnTO7PpDNB7LvB7JX09v3IjuKjcPn3P5-OnLEVuWmlX24ubAP07vzKb9R2fwGcjyTIA</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Choi, Yoon Young</creator><creator>Bae, Jung Min</creator><creator>An, Ji Yeong</creator><creator>Kwon, In Gyu</creator><creator>Cho, In</creator><creator>Shin, Hyun Beak</creator><creator>Eiji, Tanaka</creator><creator>Aburahmah, Mohammad</creator><creator>Kim, Hyung-Il</creator><creator>Cheong, Jae-Ho</creator><creator>Hyung, Woo Jin</creator><creator>Noh, Sung Hoon</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta-analysis</title><author>Choi, Yoon Young ; Bae, Jung Min ; An, Ji Yeong ; Kwon, In Gyu ; Cho, In ; Shin, Hyun Beak ; Eiji, Tanaka ; Aburahmah, Mohammad ; Kim, Hyung-Il ; Cheong, Jae-Ho ; Hyung, Woo Jin ; Noh, Sung Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-dca2a70e238ab5ce9d7e628eb91e92c5abb11667f6a24184593aef1aa8ece2e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - mortality</topic><topic>gastric cancer</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Microsatellite Instability</topic><topic>Models, Statistical</topic><topic>MSI</topic><topic>Prognosis</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - mortality</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Yoon Young</creatorcontrib><creatorcontrib>Bae, Jung Min</creatorcontrib><creatorcontrib>An, Ji Yeong</creatorcontrib><creatorcontrib>Kwon, In Gyu</creatorcontrib><creatorcontrib>Cho, In</creatorcontrib><creatorcontrib>Shin, Hyun Beak</creatorcontrib><creatorcontrib>Eiji, Tanaka</creatorcontrib><creatorcontrib>Aburahmah, Mohammad</creatorcontrib><creatorcontrib>Kim, Hyung-Il</creatorcontrib><creatorcontrib>Cheong, Jae-Ho</creatorcontrib><creatorcontrib>Hyung, Woo Jin</creatorcontrib><creatorcontrib>Noh, Sung Hoon</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Yoon Young</au><au>Bae, Jung Min</au><au>An, Ji Yeong</au><au>Kwon, In Gyu</au><au>Cho, In</au><au>Shin, Hyun Beak</au><au>Eiji, Tanaka</au><au>Aburahmah, Mohammad</au><au>Kim, Hyung-Il</au><au>Cheong, Jae-Ho</au><au>Hyung, Woo Jin</au><au>Noh, Sung Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta-analysis</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>110</volume><issue>2</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objective
The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta‐analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer.
Methods
A comprehensive systematic review and meta‐analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to “microsatellite instability,” “gastric cancer,” and “prognosis.”
Results
Twenty‐four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non‐MSI was 0.72 (95%CI: 0.59–0.88, P = .001) in a random‐effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity.
Conclusion
MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies. J. Surg. Oncol. 2014; 110:129–135. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24737677</pmid><doi>10.1002/jso.23618</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - mortality gastric cancer Genetic Markers Humans Microsatellite Instability Models, Statistical MSI Prognosis Stomach Neoplasms - genetics Stomach Neoplasms - mortality Survival Analysis |
| title | Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta-analysis |
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