Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in rats

ABSTRACT We identify changes in the expression and localization of α5, α4, and α2 integrins during osteoarthritis (OA) pathogenesis in a rat experimental model. The changes were concomitant with variations in the extracellular matrix (ECM) content and the increase of metalloproteinases (MMPs) activi...

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Veröffentlicht in:	Journal of orthopaedic research 2014-09, Vol.32 (9), p.1161-1166
Hauptverfasser:	Almonte-Becerril, Maylin, Costell, María, Kouri, Juan Bautista
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal ECM Extracellular Matrix - metabolism fibronectin Fibronectins - metabolism Hyaluronan Receptors - metabolism Integrin alpha2 - metabolism Integrin alpha4 - metabolism Integrin alpha5 - metabolism Male Metalloproteases - metabolism osteoarthritis Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Proteoglycans - metabolism Rats Rats, Wistar Severity of Illness Index α2 integrin α4 integrin α5 integrin
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