Schistocytes in disseminated intravascular coagulation
Summary Introduction The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial. Methods We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs. Results Thirty of 35 p...
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| Veröffentlicht in: | International journal of laboratory hematology 2014-08, Vol.36 (4), p.439-443 |
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| container_title | International journal of laboratory hematology |
| container_volume | 36 |
| creator | Lesesve, J.-F. Martin, M. Banasiak, C. André-Kerneïs, E. Bardet, V. Lusina, D. Kharbach, A. Geneviève, F. Lecompte, T. |
| description | Summary
Introduction
The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial.
Methods
We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs.
Results
Thirty of 35 patients presented with schistocytes and 22 with acanthocytes, which was the commonest shape anomaly. Mean percentage ± standard deviation was 0.33 ± 0.38%, median value was 0.1%, and range was 0–1.4%. The patients with schistocytes ≥ 1% had circumstances frequently associated with increased schistocytes count (promyelocytic leukaemia, pregnancy, severe infection).
Discussion
Schistocytes were thus frequently observed in DIC patients, usually with low percentage, within or close to the reference range ( |
| doi_str_mv | 10.1111/ijlh.12168 |
| format | Article |
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Introduction
The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial.
Methods
We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs.
Results
Thirty of 35 patients presented with schistocytes and 22 with acanthocytes, which was the commonest shape anomaly. Mean percentage ± standard deviation was 0.33 ± 0.38%, median value was 0.1%, and range was 0–1.4%. The patients with schistocytes ≥ 1% had circumstances frequently associated with increased schistocytes count (promyelocytic leukaemia, pregnancy, severe infection).
Discussion
Schistocytes were thus frequently observed in DIC patients, usually with low percentage, within or close to the reference range (<0.5%). Schistocytes measurement is not a clue test for the initial diagnosis of DIC, but might be of clinical value to suggest an associated or underlying thrombotic microangiopathy if ≥ 1%.</description><identifier>ISSN: 1751-5521</identifier><identifier>EISSN: 1751-553X</identifier><identifier>DOI: 10.1111/ijlh.12168</identifier><identifier>PMID: 24261329</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>acanthocyte ; Adult ; Aged ; Aged, 80 and over ; Cell Shape ; disseminated intravascular coagulation ; Disseminated Intravascular Coagulation - complications ; Disseminated Intravascular Coagulation - pathology ; Erythrocyte Count ; Erythrocytes, Abnormal - pathology ; Female ; Humans ; Intensive Care Units ; Leukemia, Promyelocytic, Acute - complications ; Leukemia, Promyelocytic, Acute - pathology ; Male ; Middle Aged ; Schistocyte ; sepsis ; Shock, Septic - complications ; Shock, Septic - pathology ; Thrombotic Microangiopathies - complications ; Thrombotic Microangiopathies - pathology ; thrombotic microangiopathy</subject><ispartof>International journal of laboratory hematology, 2014-08, Vol.36 (4), p.439-443</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3678-64ecf5fbf70b3cb6b8cf73fd75ccf0ee8ce6c9a75a367bddf4d0ac814e6168cc3</citedby><cites>FETCH-LOGICAL-c3678-64ecf5fbf70b3cb6b8cf73fd75ccf0ee8ce6c9a75a367bddf4d0ac814e6168cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijlh.12168$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijlh.12168$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24261329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lesesve, J.-F.</creatorcontrib><creatorcontrib>Martin, M.</creatorcontrib><creatorcontrib>Banasiak, C.</creatorcontrib><creatorcontrib>André-Kerneïs, E.</creatorcontrib><creatorcontrib>Bardet, V.</creatorcontrib><creatorcontrib>Lusina, D.</creatorcontrib><creatorcontrib>Kharbach, A.</creatorcontrib><creatorcontrib>Geneviève, F.</creatorcontrib><creatorcontrib>Lecompte, T.</creatorcontrib><title>Schistocytes in disseminated intravascular coagulation</title><title>International journal of laboratory hematology</title><addtitle>Int. Jnl. Lab. Hem</addtitle><description>Summary
Introduction
The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial.
Methods
We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs.
Results
Thirty of 35 patients presented with schistocytes and 22 with acanthocytes, which was the commonest shape anomaly. Mean percentage ± standard deviation was 0.33 ± 0.38%, median value was 0.1%, and range was 0–1.4%. The patients with schistocytes ≥ 1% had circumstances frequently associated with increased schistocytes count (promyelocytic leukaemia, pregnancy, severe infection).
Discussion
Schistocytes were thus frequently observed in DIC patients, usually with low percentage, within or close to the reference range (<0.5%). Schistocytes measurement is not a clue test for the initial diagnosis of DIC, but might be of clinical value to suggest an associated or underlying thrombotic microangiopathy if ≥ 1%.</description><subject>acanthocyte</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cell Shape</subject><subject>disseminated intravascular coagulation</subject><subject>Disseminated Intravascular Coagulation - complications</subject><subject>Disseminated Intravascular Coagulation - pathology</subject><subject>Erythrocyte Count</subject><subject>Erythrocytes, Abnormal - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Leukemia, Promyelocytic, Acute - complications</subject><subject>Leukemia, Promyelocytic, Acute - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Schistocyte</subject><subject>sepsis</subject><subject>Shock, Septic - complications</subject><subject>Shock, Septic - pathology</subject><subject>Thrombotic Microangiopathies - complications</subject><subject>Thrombotic Microangiopathies - pathology</subject><subject>thrombotic microangiopathy</subject><issn>1751-5521</issn><issn>1751-553X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PAjEQhhujEUQv_gDD0ZgsbrfbdjkqUcCsGKOCt6Y720pxP3C7qPx7i4scncvMJM-8yTwInWK_h11dmkU27-EAs2gPtTGn2KOUvO7v5gC30JG1C9-nPPT7h6gVhAHDJOi3EXuCubF1Ceta2a4puqmxVuWmkLVK3V5X8lNaWGWy6kIp39xQm7I4RgdaZladbHsHvdzePA9GXvwwHA-uYg8I45HHQgWa6kRzPyGQsCQCzYlOOQXQvlIRKAZ9yal0eJKmOkx9CREOFXPfAJAOOm9yl1X5sVK2FrmxoLJMFqpcWYFpyCnhQcQdetGgUJXWVkqLZWVyWa0F9sXGk9h4Er-eHHy2zV0luUp36J8YB-AG-DKZWv8TJcZ38egv1GtunFD1vbuR1btgnHAqZpOhmE6v49mEPYp78gONcYQk</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Lesesve, J.-F.</creator><creator>Martin, M.</creator><creator>Banasiak, C.</creator><creator>André-Kerneïs, E.</creator><creator>Bardet, V.</creator><creator>Lusina, D.</creator><creator>Kharbach, A.</creator><creator>Geneviève, F.</creator><creator>Lecompte, T.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Schistocytes in disseminated intravascular coagulation</title><author>Lesesve, J.-F. ; Martin, M. ; Banasiak, C. ; André-Kerneïs, E. ; Bardet, V. ; Lusina, D. ; Kharbach, A. ; Geneviève, F. ; Lecompte, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3678-64ecf5fbf70b3cb6b8cf73fd75ccf0ee8ce6c9a75a367bddf4d0ac814e6168cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>acanthocyte</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cell Shape</topic><topic>disseminated intravascular coagulation</topic><topic>Disseminated Intravascular Coagulation - complications</topic><topic>Disseminated Intravascular Coagulation - pathology</topic><topic>Erythrocyte Count</topic><topic>Erythrocytes, Abnormal - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Leukemia, Promyelocytic, Acute - complications</topic><topic>Leukemia, Promyelocytic, Acute - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Schistocyte</topic><topic>sepsis</topic><topic>Shock, Septic - complications</topic><topic>Shock, Septic - pathology</topic><topic>Thrombotic Microangiopathies - complications</topic><topic>Thrombotic Microangiopathies - pathology</topic><topic>thrombotic microangiopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lesesve, J.-F.</creatorcontrib><creatorcontrib>Martin, M.</creatorcontrib><creatorcontrib>Banasiak, C.</creatorcontrib><creatorcontrib>André-Kerneïs, E.</creatorcontrib><creatorcontrib>Bardet, V.</creatorcontrib><creatorcontrib>Lusina, D.</creatorcontrib><creatorcontrib>Kharbach, A.</creatorcontrib><creatorcontrib>Geneviève, F.</creatorcontrib><creatorcontrib>Lecompte, T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of laboratory hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lesesve, J.-F.</au><au>Martin, M.</au><au>Banasiak, C.</au><au>André-Kerneïs, E.</au><au>Bardet, V.</au><au>Lusina, D.</au><au>Kharbach, A.</au><au>Geneviève, F.</au><au>Lecompte, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schistocytes in disseminated intravascular coagulation</atitle><jtitle>International journal of laboratory hematology</jtitle><addtitle>Int. Jnl. Lab. Hem</addtitle><date>2014-08</date><risdate>2014</risdate><volume>36</volume><issue>4</issue><spage>439</spage><epage>443</epage><pages>439-443</pages><issn>1751-5521</issn><eissn>1751-553X</eissn><abstract>Summary
Introduction
The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial.
Methods
We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs.
Results
Thirty of 35 patients presented with schistocytes and 22 with acanthocytes, which was the commonest shape anomaly. Mean percentage ± standard deviation was 0.33 ± 0.38%, median value was 0.1%, and range was 0–1.4%. The patients with schistocytes ≥ 1% had circumstances frequently associated with increased schistocytes count (promyelocytic leukaemia, pregnancy, severe infection).
Discussion
Schistocytes were thus frequently observed in DIC patients, usually with low percentage, within or close to the reference range (<0.5%). Schistocytes measurement is not a clue test for the initial diagnosis of DIC, but might be of clinical value to suggest an associated or underlying thrombotic microangiopathy if ≥ 1%.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24261329</pmid><doi>10.1111/ijlh.12168</doi><tpages>5</tpages></addata></record> |
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| subjects | acanthocyte Adult Aged Aged, 80 and over Cell Shape disseminated intravascular coagulation Disseminated Intravascular Coagulation - complications Disseminated Intravascular Coagulation - pathology Erythrocyte Count Erythrocytes, Abnormal - pathology Female Humans Intensive Care Units Leukemia, Promyelocytic, Acute - complications Leukemia, Promyelocytic, Acute - pathology Male Middle Aged Schistocyte sepsis Shock, Septic - complications Shock, Septic - pathology Thrombotic Microangiopathies - complications Thrombotic Microangiopathies - pathology thrombotic microangiopathy |
| title | Schistocytes in disseminated intravascular coagulation |
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