Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and type 2 diabetes: Action LADA 9 [corrected]
To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with type 2 diabetes. A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independen...
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| Veröffentlicht in: | Diabetic medicine 2014-08, Vol.31 (8), p.941-945 |
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| container_title | Diabetic medicine |
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| creator | Juhl, C B Bradley, U Holst, J J Leslie, R D Yderstraede, K B Hunter, S |
| description | To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with type 2 diabetes.
A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with type 2 diabetes (group B) and to six people with type 2 diabetes of similar age and BMI (group C). β-Cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.
Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.
We found no evidence that LADA and type 2 diabetes were distinct disease entities beyond the differences explained by BMI. |
| doi_str_mv | 10.1111/dme.12434 |
| format | Article |
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A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with type 2 diabetes (group B) and to six people with type 2 diabetes of similar age and BMI (group C). β-Cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.
Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.
We found no evidence that LADA and type 2 diabetes were distinct disease entities beyond the differences explained by BMI.</description><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.12434</identifier><identifier>PMID: 24628669</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Age of Onset ; Autoantibodies - analysis ; Autoimmune Diseases - complications ; Autoimmune Diseases - drug therapy ; Autoimmune Diseases - epidemiology ; Autoimmune Diseases - metabolism ; Blood Glucose - analysis ; Body Mass Index ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Glucose Clamp Technique ; Glutamate Decarboxylase - antagonists & inhibitors ; Humans ; Hypoglycemic Agents - therapeutic use ; Incretins - blood ; Incretins - metabolism ; Insulin - blood ; Insulin - metabolism ; Insulin - therapeutic use ; Insulin Resistance ; Insulin Secretion ; Insulin-Secreting Cells - drug effects ; Insulin-Secreting Cells - metabolism ; Matched-Pair Analysis ; Obesity - complications ; Overweight - complications ; Postprandial Period</subject><ispartof>Diabetic medicine, 2014-08, Vol.31 (8), p.941-945</ispartof><rights>2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24628669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juhl, C B</creatorcontrib><creatorcontrib>Bradley, U</creatorcontrib><creatorcontrib>Holst, J J</creatorcontrib><creatorcontrib>Leslie, R D</creatorcontrib><creatorcontrib>Yderstraede, K B</creatorcontrib><creatorcontrib>Hunter, S</creatorcontrib><creatorcontrib>Action LADA Consortium</creatorcontrib><title>Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and type 2 diabetes: Action LADA 9 [corrected]</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with type 2 diabetes.
A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with type 2 diabetes (group B) and to six people with type 2 diabetes of similar age and BMI (group C). β-Cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.
Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.
We found no evidence that LADA and type 2 diabetes were distinct disease entities beyond the differences explained by BMI.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Autoantibodies - analysis</subject><subject>Autoimmune Diseases - complications</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Glucose Clamp Technique</subject><subject>Glutamate Decarboxylase - antagonists & inhibitors</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Incretins - blood</subject><subject>Incretins - metabolism</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin - therapeutic use</subject><subject>Insulin Resistance</subject><subject>Insulin Secretion</subject><subject>Insulin-Secreting Cells - drug effects</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Matched-Pair Analysis</subject><subject>Obesity - complications</subject><subject>Overweight - complications</subject><subject>Postprandial Period</subject><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1Lw0AQhhdBbK0e_AOyx3pIzX4kabwFv6Hgwd5EwmZ3Yrck2bgfSn-Vf9G0VnEuw8w8PAwvQmcknpGhLlULM0I54wdoTHjKo4TnZISOnVvHMaE5y4_QiPKUztM0H6OvZ93qRlj8Cfpt5SOh1sF5UFh3LjS6ww6kBa9Nh0X3f9s57fWH9hu8HVfG-kgFK3ZkIzxgEbzRbRs6wEqLCjw4bGosVGj8yhiFp4viprjYaf2mB0z_uCtcyJ1oS-Acv0hjLcjhrdcTdFiLxsHpvk_Q8u52ef0QLZ7uH6-LRdQnaR7VklUZzeecZgnjnLFEpGlNpBJzklZ1LEWd18lw5qqqgMQqE5zXAwKQUVJJNkHTH21vzXsA58tWOwlNIzowwZUk4VlChwzjAT3fo6FqQZW91a2wm_I3Y_YNLYV-Ow</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Juhl, C B</creator><creator>Bradley, U</creator><creator>Holst, J J</creator><creator>Leslie, R D</creator><creator>Yderstraede, K B</creator><creator>Hunter, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and type 2 diabetes: Action LADA 9 [corrected]</title><author>Juhl, C B ; Bradley, U ; Holst, J J ; Leslie, R D ; Yderstraede, K B ; Hunter, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p569-fc3b72984275344335a66f1cda816bf0caf9f58424dbbe10d7a44f66fee721bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Autoantibodies - analysis</topic><topic>Autoimmune Diseases - complications</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Glucose Clamp Technique</topic><topic>Glutamate Decarboxylase - antagonists & inhibitors</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Incretins - blood</topic><topic>Incretins - metabolism</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Insulin - therapeutic use</topic><topic>Insulin Resistance</topic><topic>Insulin Secretion</topic><topic>Insulin-Secreting Cells - drug effects</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Matched-Pair Analysis</topic><topic>Obesity - complications</topic><topic>Overweight - complications</topic><topic>Postprandial Period</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juhl, C B</creatorcontrib><creatorcontrib>Bradley, U</creatorcontrib><creatorcontrib>Holst, J J</creatorcontrib><creatorcontrib>Leslie, R D</creatorcontrib><creatorcontrib>Yderstraede, K B</creatorcontrib><creatorcontrib>Hunter, S</creatorcontrib><creatorcontrib>Action LADA Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juhl, C B</au><au>Bradley, U</au><au>Holst, J J</au><au>Leslie, R D</au><au>Yderstraede, K B</au><au>Hunter, S</au><aucorp>Action LADA Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and type 2 diabetes: Action LADA 9 [corrected]</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2014-08</date><risdate>2014</risdate><volume>31</volume><issue>8</issue><spage>941</spage><epage>945</epage><pages>941-945</pages><eissn>1464-5491</eissn><abstract>To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with type 2 diabetes.
A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with type 2 diabetes (group B) and to six people with type 2 diabetes of similar age and BMI (group C). β-Cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.
Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.
We found no evidence that LADA and type 2 diabetes were distinct disease entities beyond the differences explained by BMI.</abstract><cop>England</cop><pmid>24628669</pmid><doi>10.1111/dme.12434</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Age of Onset Autoantibodies - analysis Autoimmune Diseases - complications Autoimmune Diseases - drug therapy Autoimmune Diseases - epidemiology Autoimmune Diseases - metabolism Blood Glucose - analysis Body Mass Index Cohort Studies Cross-Sectional Studies Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Glucose Clamp Technique Glutamate Decarboxylase - antagonists & inhibitors Humans Hypoglycemic Agents - therapeutic use Incretins - blood Incretins - metabolism Insulin - blood Insulin - metabolism Insulin - therapeutic use Insulin Resistance Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Matched-Pair Analysis Obesity - complications Overweight - complications Postprandial Period |
| title | Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and type 2 diabetes: Action LADA 9 [corrected] |
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