Skin lesions in a patient with IgG4-related disease
Summary IgG4‐related disease (IgG4‐RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4‐positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Sk...
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| Veröffentlicht in: | Clinical and experimental dermatology 2014-08, Vol.39 (6), p.713-716 |
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| container_title | Clinical and experimental dermatology |
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| creator | Ise, M. Yasuda, F. Suzaki, R. Kurihara, S. Konohana, I. |
| description | Summary
IgG4‐related disease (IgG4‐RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4‐positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that have were described as distributed mainly in the head and neck region. We report a case of IgG4‐RD with autoimmune pancreatitis and skin lesions on the trunk and limbs. The skin lesions responded well to oral prednisolone (PSL); however, tapering of PSL to 5 mg/day resulted in recurrence. At present, the skin disease is well controlled at a dose of 7 mg/day. Interestingly, IgG4 levels fluctuated with changes in the PSL dose but did not coincide with the severity of the skin disease, implying that the raised levels of IgG4 did not directly influence the skin symptoms. |
| doi_str_mv | 10.1111/ced.12372 |
| format | Article |
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IgG4‐related disease (IgG4‐RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4‐positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that have were described as distributed mainly in the head and neck region. We report a case of IgG4‐RD with autoimmune pancreatitis and skin lesions on the trunk and limbs. The skin lesions responded well to oral prednisolone (PSL); however, tapering of PSL to 5 mg/day resulted in recurrence. At present, the skin disease is well controlled at a dose of 7 mg/day. Interestingly, IgG4 levels fluctuated with changes in the PSL dose but did not coincide with the severity of the skin disease, implying that the raised levels of IgG4 did not directly influence the skin symptoms.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.12372</identifier><identifier>PMID: 24986022</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Autoimmune Diseases - drug therapy ; Autoimmune Diseases - immunology ; Glucocorticoids - therapeutic use ; Humans ; Immunoglobulin G - immunology ; Male ; Middle Aged ; Pancreatitis - drug therapy ; Pancreatitis - immunology ; Prednisolone - therapeutic use ; Recurrence ; Skin Diseases - drug therapy ; Skin Diseases - immunology</subject><ispartof>Clinical and experimental dermatology, 2014-08, Vol.39 (6), p.713-716</ispartof><rights>2014 British Association of Dermatologists</rights><rights>2014 British Association of Dermatologists.</rights><rights>Copyright © 2014 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3912-fe360055d832e91ab187bb3d19435cd7242125d754ab84138631630eb3ac3ecc3</citedby><cites>FETCH-LOGICAL-c3912-fe360055d832e91ab187bb3d19435cd7242125d754ab84138631630eb3ac3ecc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24986022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ise, M.</creatorcontrib><creatorcontrib>Yasuda, F.</creatorcontrib><creatorcontrib>Suzaki, R.</creatorcontrib><creatorcontrib>Kurihara, S.</creatorcontrib><creatorcontrib>Konohana, I.</creatorcontrib><title>Skin lesions in a patient with IgG4-related disease</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
IgG4‐related disease (IgG4‐RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4‐positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that have were described as distributed mainly in the head and neck region. We report a case of IgG4‐RD with autoimmune pancreatitis and skin lesions on the trunk and limbs. The skin lesions responded well to oral prednisolone (PSL); however, tapering of PSL to 5 mg/day resulted in recurrence. At present, the skin disease is well controlled at a dose of 7 mg/day. Interestingly, IgG4 levels fluctuated with changes in the PSL dose but did not coincide with the severity of the skin disease, implying that the raised levels of IgG4 did not directly influence the skin symptoms.</description><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - immunology</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatitis - drug therapy</subject><subject>Pancreatitis - immunology</subject><subject>Prednisolone - therapeutic use</subject><subject>Recurrence</subject><subject>Skin Diseases - drug therapy</subject><subject>Skin Diseases - immunology</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10F1LwzAUBuAgipsfF_4BKXijF9Ukp2naS51zG4ii8wN2E9L2TLN17Wxa5v690W1eCOYmITzn5fAScsToOXPnIsXsnHGQfIu0GYTC5xzoNmlToNIPY4haZM_aCaUMmBS7pMWDOAop520Cw6kpvBytKQvruaf25ro2WNTewtTv3uCtF_gV5rrGzMuMRW3xgOyMdW7xcH3vk-eb7lOn79_e9wady1s_hZhxf4wQUipEFgHHmOmERTJJIGNxACLNJA844yKTItBJFDCIQmAhUExAp4BpCvvkdJU7r8qPBm2tZsammOe6wLKxiolACk5joI6e_KGTsqkKt923EtQtFAZOna1UWpXWVjhW88rMdLVUjKrvJpVrUv006ezxOrFJZu53IzfVOXCxAguT4_L_JNXpXm8i_dWEsTV-_k7oaqpCCVKo17ueehkNH0e9_oO6gi8vFYhH</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Ise, M.</creator><creator>Yasuda, F.</creator><creator>Suzaki, R.</creator><creator>Kurihara, S.</creator><creator>Konohana, I.</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Skin lesions in a patient with IgG4-related disease</title><author>Ise, M. ; Yasuda, F. ; Suzaki, R. ; Kurihara, S. ; Konohana, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3912-fe360055d832e91ab187bb3d19435cd7242125d754ab84138631630eb3ac3ecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Autoimmune Diseases - drug therapy</topic><topic>Autoimmune Diseases - immunology</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatitis - drug therapy</topic><topic>Pancreatitis - immunology</topic><topic>Prednisolone - therapeutic use</topic><topic>Recurrence</topic><topic>Skin Diseases - drug therapy</topic><topic>Skin Diseases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ise, M.</creatorcontrib><creatorcontrib>Yasuda, F.</creatorcontrib><creatorcontrib>Suzaki, R.</creatorcontrib><creatorcontrib>Kurihara, S.</creatorcontrib><creatorcontrib>Konohana, I.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ise, M.</au><au>Yasuda, F.</au><au>Suzaki, R.</au><au>Kurihara, S.</au><au>Konohana, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin lesions in a patient with IgG4-related disease</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>39</volume><issue>6</issue><spage>713</spage><epage>716</epage><pages>713-716</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
IgG4‐related disease (IgG4‐RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4‐positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that have were described as distributed mainly in the head and neck region. We report a case of IgG4‐RD with autoimmune pancreatitis and skin lesions on the trunk and limbs. The skin lesions responded well to oral prednisolone (PSL); however, tapering of PSL to 5 mg/day resulted in recurrence. At present, the skin disease is well controlled at a dose of 7 mg/day. Interestingly, IgG4 levels fluctuated with changes in the PSL dose but did not coincide with the severity of the skin disease, implying that the raised levels of IgG4 did not directly influence the skin symptoms.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24986022</pmid><doi>10.1111/ced.12372</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2014-08, Vol.39 (6), p.713-716 |
| issn | 0307-6938 1365-2230 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Glucocorticoids - therapeutic use Humans Immunoglobulin G - immunology Male Middle Aged Pancreatitis - drug therapy Pancreatitis - immunology Prednisolone - therapeutic use Recurrence Skin Diseases - drug therapy Skin Diseases - immunology |
| title | Skin lesions in a patient with IgG4-related disease |
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