Circulating gamma-glutamyltransferase fractions in cirrhosis
Background & Aims Four gamma‐gultamyltransferases (GGT) fractions (b‐, m‐, s‐, and f‐GGT) have been identified in human plasma and their concentrations and ratios vary in different pathological conditions. To assess the behaviour of fractional GGT in cirrhotic patients evaluated for liver transp...
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| Veröffentlicht in: | Liver international 2014-08, Vol.34 (7), p.e191-e199 |
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| creator | Elawdi, Hassan A. Franzini, Maria Paolicchi, Aldo Emdin, Michele Fornaciari, Irene Fierabracci, Vanna De Simone, Paolo Carrai, Paola Filipponi, Franco |
| description | Background & Aims
Four gamma‐gultamyltransferases (GGT) fractions (b‐, m‐, s‐, and f‐GGT) have been identified in human plasma and their concentrations and ratios vary in different pathological conditions. To assess the behaviour of fractional GGT in cirrhotic patients evaluated for liver transplantation.
Methods
This was a single‐centre, cross‐sectional study; GGT fractions were determined by gel‐filtration chromatography.
Results
264 cirrhotic patients (215 males; median age 54.5 years) were included and compared against a group of 200 healthy individuals (100 males; median age 41.5). Median (25th–75th percentile) total and fractional GGT were higher in cirrhotics, with s‐GGT showing the greatest increase [36.6 U/L (21.0–81.4) vs. 5.6 U/L (3.2–10.2), P |
| doi_str_mv | 10.1111/liv.12455 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1547520067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1547520067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5345-e85263fcd838cd4a68a8012053b6428207ef440c9dfb77d97a411dd099d82b273</originalsourceid><addsrcrecordid>eNp1kD1PwzAURS0EolAY-AMoIwxp_Rk7EgtUUCpVMABltBzHKQYnKXYC9N-T0o-Nt7w3nHv1dAA4Q3CAuhk6-zVAmDK2B44Q5SImmKD93Y1JDxyH8A4hSlOGDkEPUyJ4wpMjcDWyXrdONbaaR3NVliqeu7ZR5dI1XlWhMF4FExVe6cbWVYhsFWnr_VsdbDgBB4VywZxudh-83N0-j-7j6eN4MrqexpoRymIjGE5IoXNBhM6pSoQSEGHISJZQLDDkpqAU6jQvMs7zlCuKUJ7DNM0FzjAnfXCx7l34-rM1oZGlDdo4pypTt0EiRjnDECYr9HKNal-H4E0hF96Wyi8lgnIlS3ay5J-sjj3f1LZZafIdubXTAcM18G2dWf7fJKeT2bYyXidsaMzPLqH8h-ye40y-PoxlimezG4ie5Jj8Alt-giM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547520067</pqid></control><display><type>article</type><title>Circulating gamma-glutamyltransferase fractions in cirrhosis</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Elawdi, Hassan A. ; Franzini, Maria ; Paolicchi, Aldo ; Emdin, Michele ; Fornaciari, Irene ; Fierabracci, Vanna ; De Simone, Paolo ; Carrai, Paola ; Filipponi, Franco</creator><creatorcontrib>Elawdi, Hassan A. ; Franzini, Maria ; Paolicchi, Aldo ; Emdin, Michele ; Fornaciari, Irene ; Fierabracci, Vanna ; De Simone, Paolo ; Carrai, Paola ; Filipponi, Franco</creatorcontrib><description>Background & Aims
Four gamma‐gultamyltransferases (GGT) fractions (b‐, m‐, s‐, and f‐GGT) have been identified in human plasma and their concentrations and ratios vary in different pathological conditions. To assess the behaviour of fractional GGT in cirrhotic patients evaluated for liver transplantation.
Methods
This was a single‐centre, cross‐sectional study; GGT fractions were determined by gel‐filtration chromatography.
Results
264 cirrhotic patients (215 males; median age 54.5 years) were included and compared against a group of 200 healthy individuals (100 males; median age 41.5). Median (25th–75th percentile) total and fractional GGT were higher in cirrhotics, with s‐GGT showing the greatest increase [36.6 U/L (21.0–81.4) vs. 5.6 U/L (3.2–10.2), P < 0.0001], while the median b‐GGT/s‐GGT ratio was lower in cirrhotics than in healthy controls [0.06 (0.04–0.10)] vs. 0.28 (0.20–0.40), P < 0.0001]. The ratio showed higher diagnostic accuracy (ROC‐AUC, 95% CI: 0.951, 0.927–0.969) then either s‐GGT (0.924, 0.897–0.947; P < 0.05) or total GGT (0.900, 0.869–0.925; P < 0.001). The diagnostic accuracy of the ratio was maintained (0.940, 0.907–0.963) in cirrhotic patients (n = 113) with total GGT values within the reference range. The s‐GGT fraction consisted of two components, with one (s2‐GGT) showing a significant positive correlation with serum aspartate aminotransferases, alanine aminotransferase, lactate dehydrogenases (LDH), alkaline phosphatases and bilirubin, and negative with albumin. The b‐GGT fraction showed a positive correlation with albumin, fibrinogen, and platelet counts, and negative with international normalized ratio, bilirubin and LDH.
Conclusions
The ratio performs as a sensitive biomarker of the liver parenchymal rearrangement, irrespective of aetiology of cirrhosis and presence of hepatocellular carcinoma, even in patients with total GGT values within the reference range.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.12455</identifier><identifier>PMID: 24387676</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alanine Transaminase - blood ; Alkaline Phosphatase - blood ; Aspartate Aminotransferases - blood ; b-GGT/s-GGT ratio ; Bilirubin ; Chromatography, Gel ; cirrhosis ; Cross-Sectional Studies ; end-stage liver disease ; Female ; fractions ; gamma-glutamyltransferase ; gamma-Glutamyltransferase - blood ; Humans ; Italy ; L-Lactate Dehydrogenase - blood ; L-Lactate Dehydrogenase - metabolism ; Liver Cirrhosis - blood ; Liver Cirrhosis - pathology ; Male ; Middle Aged ; ROC Curve</subject><ispartof>Liver international, 2014-08, Vol.34 (7), p.e191-e199</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5345-e85263fcd838cd4a68a8012053b6428207ef440c9dfb77d97a411dd099d82b273</citedby><cites>FETCH-LOGICAL-c5345-e85263fcd838cd4a68a8012053b6428207ef440c9dfb77d97a411dd099d82b273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.12455$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.12455$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24387676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elawdi, Hassan A.</creatorcontrib><creatorcontrib>Franzini, Maria</creatorcontrib><creatorcontrib>Paolicchi, Aldo</creatorcontrib><creatorcontrib>Emdin, Michele</creatorcontrib><creatorcontrib>Fornaciari, Irene</creatorcontrib><creatorcontrib>Fierabracci, Vanna</creatorcontrib><creatorcontrib>De Simone, Paolo</creatorcontrib><creatorcontrib>Carrai, Paola</creatorcontrib><creatorcontrib>Filipponi, Franco</creatorcontrib><title>Circulating gamma-glutamyltransferase fractions in cirrhosis</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background & Aims
Four gamma‐gultamyltransferases (GGT) fractions (b‐, m‐, s‐, and f‐GGT) have been identified in human plasma and their concentrations and ratios vary in different pathological conditions. To assess the behaviour of fractional GGT in cirrhotic patients evaluated for liver transplantation.
Methods
This was a single‐centre, cross‐sectional study; GGT fractions were determined by gel‐filtration chromatography.
Results
264 cirrhotic patients (215 males; median age 54.5 years) were included and compared against a group of 200 healthy individuals (100 males; median age 41.5). Median (25th–75th percentile) total and fractional GGT were higher in cirrhotics, with s‐GGT showing the greatest increase [36.6 U/L (21.0–81.4) vs. 5.6 U/L (3.2–10.2), P < 0.0001], while the median b‐GGT/s‐GGT ratio was lower in cirrhotics than in healthy controls [0.06 (0.04–0.10)] vs. 0.28 (0.20–0.40), P < 0.0001]. The ratio showed higher diagnostic accuracy (ROC‐AUC, 95% CI: 0.951, 0.927–0.969) then either s‐GGT (0.924, 0.897–0.947; P < 0.05) or total GGT (0.900, 0.869–0.925; P < 0.001). The diagnostic accuracy of the ratio was maintained (0.940, 0.907–0.963) in cirrhotic patients (n = 113) with total GGT values within the reference range. The s‐GGT fraction consisted of two components, with one (s2‐GGT) showing a significant positive correlation with serum aspartate aminotransferases, alanine aminotransferase, lactate dehydrogenases (LDH), alkaline phosphatases and bilirubin, and negative with albumin. The b‐GGT fraction showed a positive correlation with albumin, fibrinogen, and platelet counts, and negative with international normalized ratio, bilirubin and LDH.
Conclusions
The ratio performs as a sensitive biomarker of the liver parenchymal rearrangement, irrespective of aetiology of cirrhosis and presence of hepatocellular carcinoma, even in patients with total GGT values within the reference range.</description><subject>Alanine Transaminase - blood</subject><subject>Alkaline Phosphatase - blood</subject><subject>Aspartate Aminotransferases - blood</subject><subject>b-GGT/s-GGT ratio</subject><subject>Bilirubin</subject><subject>Chromatography, Gel</subject><subject>cirrhosis</subject><subject>Cross-Sectional Studies</subject><subject>end-stage liver disease</subject><subject>Female</subject><subject>fractions</subject><subject>gamma-glutamyltransferase</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Humans</subject><subject>Italy</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>ROC Curve</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EolAY-AMoIwxp_Rk7EgtUUCpVMABltBzHKQYnKXYC9N-T0o-Nt7w3nHv1dAA4Q3CAuhk6-zVAmDK2B44Q5SImmKD93Y1JDxyH8A4hSlOGDkEPUyJ4wpMjcDWyXrdONbaaR3NVliqeu7ZR5dI1XlWhMF4FExVe6cbWVYhsFWnr_VsdbDgBB4VywZxudh-83N0-j-7j6eN4MrqexpoRymIjGE5IoXNBhM6pSoQSEGHISJZQLDDkpqAU6jQvMs7zlCuKUJ7DNM0FzjAnfXCx7l34-rM1oZGlDdo4pypTt0EiRjnDECYr9HKNal-H4E0hF96Wyi8lgnIlS3ay5J-sjj3f1LZZafIdubXTAcM18G2dWf7fJKeT2bYyXidsaMzPLqH8h-ye40y-PoxlimezG4ie5Jj8Alt-giM</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Elawdi, Hassan A.</creator><creator>Franzini, Maria</creator><creator>Paolicchi, Aldo</creator><creator>Emdin, Michele</creator><creator>Fornaciari, Irene</creator><creator>Fierabracci, Vanna</creator><creator>De Simone, Paolo</creator><creator>Carrai, Paola</creator><creator>Filipponi, Franco</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Circulating gamma-glutamyltransferase fractions in cirrhosis</title><author>Elawdi, Hassan A. ; Franzini, Maria ; Paolicchi, Aldo ; Emdin, Michele ; Fornaciari, Irene ; Fierabracci, Vanna ; De Simone, Paolo ; Carrai, Paola ; Filipponi, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5345-e85263fcd838cd4a68a8012053b6428207ef440c9dfb77d97a411dd099d82b273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alanine Transaminase - blood</topic><topic>Alkaline Phosphatase - blood</topic><topic>Aspartate Aminotransferases - blood</topic><topic>b-GGT/s-GGT ratio</topic><topic>Bilirubin</topic><topic>Chromatography, Gel</topic><topic>cirrhosis</topic><topic>Cross-Sectional Studies</topic><topic>end-stage liver disease</topic><topic>Female</topic><topic>fractions</topic><topic>gamma-glutamyltransferase</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Humans</topic><topic>Italy</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>ROC Curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elawdi, Hassan A.</creatorcontrib><creatorcontrib>Franzini, Maria</creatorcontrib><creatorcontrib>Paolicchi, Aldo</creatorcontrib><creatorcontrib>Emdin, Michele</creatorcontrib><creatorcontrib>Fornaciari, Irene</creatorcontrib><creatorcontrib>Fierabracci, Vanna</creatorcontrib><creatorcontrib>De Simone, Paolo</creatorcontrib><creatorcontrib>Carrai, Paola</creatorcontrib><creatorcontrib>Filipponi, Franco</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elawdi, Hassan A.</au><au>Franzini, Maria</au><au>Paolicchi, Aldo</au><au>Emdin, Michele</au><au>Fornaciari, Irene</au><au>Fierabracci, Vanna</au><au>De Simone, Paolo</au><au>Carrai, Paola</au><au>Filipponi, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating gamma-glutamyltransferase fractions in cirrhosis</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2014-08</date><risdate>2014</risdate><volume>34</volume><issue>7</issue><spage>e191</spage><epage>e199</epage><pages>e191-e199</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background & Aims
Four gamma‐gultamyltransferases (GGT) fractions (b‐, m‐, s‐, and f‐GGT) have been identified in human plasma and their concentrations and ratios vary in different pathological conditions. To assess the behaviour of fractional GGT in cirrhotic patients evaluated for liver transplantation.
Methods
This was a single‐centre, cross‐sectional study; GGT fractions were determined by gel‐filtration chromatography.
Results
264 cirrhotic patients (215 males; median age 54.5 years) were included and compared against a group of 200 healthy individuals (100 males; median age 41.5). Median (25th–75th percentile) total and fractional GGT were higher in cirrhotics, with s‐GGT showing the greatest increase [36.6 U/L (21.0–81.4) vs. 5.6 U/L (3.2–10.2), P < 0.0001], while the median b‐GGT/s‐GGT ratio was lower in cirrhotics than in healthy controls [0.06 (0.04–0.10)] vs. 0.28 (0.20–0.40), P < 0.0001]. The ratio showed higher diagnostic accuracy (ROC‐AUC, 95% CI: 0.951, 0.927–0.969) then either s‐GGT (0.924, 0.897–0.947; P < 0.05) or total GGT (0.900, 0.869–0.925; P < 0.001). The diagnostic accuracy of the ratio was maintained (0.940, 0.907–0.963) in cirrhotic patients (n = 113) with total GGT values within the reference range. The s‐GGT fraction consisted of two components, with one (s2‐GGT) showing a significant positive correlation with serum aspartate aminotransferases, alanine aminotransferase, lactate dehydrogenases (LDH), alkaline phosphatases and bilirubin, and negative with albumin. The b‐GGT fraction showed a positive correlation with albumin, fibrinogen, and platelet counts, and negative with international normalized ratio, bilirubin and LDH.
Conclusions
The ratio performs as a sensitive biomarker of the liver parenchymal rearrangement, irrespective of aetiology of cirrhosis and presence of hepatocellular carcinoma, even in patients with total GGT values within the reference range.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24387676</pmid><doi>10.1111/liv.12455</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Alanine Transaminase - blood Alkaline Phosphatase - blood Aspartate Aminotransferases - blood b-GGT/s-GGT ratio Bilirubin Chromatography, Gel cirrhosis Cross-Sectional Studies end-stage liver disease Female fractions gamma-glutamyltransferase gamma-Glutamyltransferase - blood Humans Italy L-Lactate Dehydrogenase - blood L-Lactate Dehydrogenase - metabolism Liver Cirrhosis - blood Liver Cirrhosis - pathology Male Middle Aged ROC Curve |
| title | Circulating gamma-glutamyltransferase fractions in cirrhosis |
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