H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells

12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylp...

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Veröffentlicht in:	Molecular pharmacology 1989-12, Vol.36 (6), p.917-924
Hauptverfasser:	Nakadate, T, Yamamoto, S, Aizu, E, Nishikawa, K, Kato, R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured Chemical agents Enzyme Induction - drug effects epidermal growth factor Epidermal Growth Factor - metabolism epidermis Epidermis - metabolism Isoquinolines - pharmacology Medical sciences Mice ornithine decarboxylase Ornithine Decarboxylase - biosynthesis Phosphorylation Piperazines - pharmacology Protein Kinase C - antagonists & inhibitors Sphingosine - pharmacology Tetradecanoylphorbol Acetate - pharmacology Tumors
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