Inhibition by REV-5901 of leukotriene release from guinea-pig and human lung tissue in vitro

The 5-lipoxygenase inhibitor REV-5901 [α-pentyl-3-(2-quinolinylmethoxy)benzene-methanol] was evaluated for effects on mediator release in vitro from fragmented guinea-pig and human lung. In guinea-pig lung, REV-5901 inhibited the antigen-induced release of immunoreactive leukotriene D 4 (iLTD 4) wit...

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Veröffentlicht in:	Biochemical pharmacology 1989-12, Vol.38 (23), p.4183-4189
Hauptverfasser:	Kusner, Edward J., Marks, Rebecca L., Aharony, David, Krell, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcimycin - pharmacology Culture Techniques Drug Interactions Guinea Pigs Histamine - metabolism Humans Hydroxyquinolines - pharmacology Leukotriene B4 - analysis Leukotriene B4 - metabolism leukotrienes Lipoxygenase Inhibitors lung Lung - drug effects Lung - metabolism Male Prostaglandin-Endoperoxide Synthases - metabolism Quinolines SRS-A - metabolism Thromboxane B2 - analysis Time Factors
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