Consistent oncogene methylation changes in epithelial cells chemically transformed in vitro

We have examined the restriction digest patterns of CCGG sequences in Ki- ras, Ha- ras, and c- myc oncogenes in rat tracheal epithelial cells transformed in vitro by 7,12-dimethylbenz(a)anthracene, benzo(a)pyrene/12-O-tetradecanoylphorbol-13-acetate (TPA), or TPA alone. Oncogenes c- myc and Ha- ras...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-10, Vol.164 (2), p.693-699
Hauptverfasser:	Mass, Marc J., Schorschinsky, Nancy S., Lasley, Jessica A., Beeman, Diane K., Austin, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - pharmacology Animals Base Sequence Benzo(a)pyrene - pharmacology Biological and medical sciences Blotting, Southern Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cells, Cultured DNA - drug effects DNA - genetics Epithelial Cells Epithelium - drug effects Fundamental and applied biological sciences. Psychology Genes, ras - drug effects Male Methylation Molecular and cellular biology Proto-Oncogenes - drug effects Rats Rats, Inbred F344 Restriction Mapping Tetradecanoylphorbol Acetate - pharmacology Trachea
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