Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria
In this study, we have investigated the in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with 45Ca. As stimulators of bone resorption, bovine pa...
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| Veröffentlicht in: | International journal of immunopharmacology 1989, Vol.11 (8), p.953-959 |
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| container_title | International journal of immunopharmacology |
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| creator | Sasagawa, K Fujibayashi, S Okano, K Nawa, C Suzuki, S Kou, S Yamada, Y Someya, K |
| description | In this study, we have investigated the
in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with
45Ca. As stimulators of bone resorption, bovine parathyroid hormone (PTH), lipopolysaccharide (LPS), interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) were used. Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1β or TNF-α in a dose-dependent manner. Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption. Removal of lobenzarit from the culture medium resulted in the recovery of bone resorptive activity. These results suggest that the inhibitory effect of immunomodulators on bone resorption is reversible and nonselective. Also, it raises the possibility that immunomodulators and immunosuppressants may affect bone resorption by different mechanisms. |
| doi_str_mv | 10.1016/0192-0561(89)90118-5 |
| format | Article |
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in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with
45Ca. As stimulators of bone resorption, bovine parathyroid hormone (PTH), lipopolysaccharide (LPS), interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) were used. Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1β or TNF-α in a dose-dependent manner. Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption. Removal of lobenzarit from the culture medium resulted in the recovery of bone resorptive activity. These results suggest that the inhibitory effect of immunomodulators on bone resorption is reversible and nonselective. Also, it raises the possibility that immunomodulators and immunosuppressants may affect bone resorption by different mechanisms.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(89)90118-5</identifier><identifier>PMID: 2613398</identifier><language>eng</language><publisher>England: Elsevier Science</publisher><subject>Adjuvants, Immunologic - pharmacology ; Animals ; Bone Resorption - chemically induced ; Bone Resorption - prevention & control ; Chromones - pharmacology ; Cyclosporins - pharmacology ; Immunosuppressive Agents - pharmacology ; In Vitro Techniques ; Interleukin-1 - pharmacology ; Lipopolysaccharides - pharmacology ; Mice ; Mice, Inbred ICR ; ortho-Aminobenzoates - pharmacology ; Parathyroid Hormone - pharmacology ; Ribonucleosides - pharmacology ; Tumor Necrosis Factor-alpha - pharmacology</subject><ispartof>International journal of immunopharmacology, 1989, Vol.11 (8), p.953-959</ispartof><rights>1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-57b240f3a757e5a3f3e6cce728d395490d5736acc2b6656bf003e0ed8c14718e3</citedby><cites>FETCH-LOGICAL-c454t-57b240f3a757e5a3f3e6cce728d395490d5736acc2b6656bf003e0ed8c14718e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2613398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasagawa, K</creatorcontrib><creatorcontrib>Fujibayashi, S</creatorcontrib><creatorcontrib>Okano, K</creatorcontrib><creatorcontrib>Nawa, C</creatorcontrib><creatorcontrib>Suzuki, S</creatorcontrib><creatorcontrib>Kou, S</creatorcontrib><creatorcontrib>Yamada, Y</creatorcontrib><creatorcontrib>Someya, K</creatorcontrib><title>Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>In this study, we have investigated the
in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with
45Ca. As stimulators of bone resorption, bovine parathyroid hormone (PTH), lipopolysaccharide (LPS), interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) were used. Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1β or TNF-α in a dose-dependent manner. Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption. Removal of lobenzarit from the culture medium resulted in the recovery of bone resorptive activity. These results suggest that the inhibitory effect of immunomodulators on bone resorption is reversible and nonselective. Also, it raises the possibility that immunomodulators and immunosuppressants may affect bone resorption by different mechanisms.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Bone Resorption - chemically induced</subject><subject>Bone Resorption - prevention & control</subject><subject>Chromones - pharmacology</subject><subject>Cyclosporins - pharmacology</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Interleukin-1 - pharmacology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>ortho-Aminobenzoates - pharmacology</subject><subject>Parathyroid Hormone - pharmacology</subject><subject>Ribonucleosides - pharmacology</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtO5DAQRS00iGkef8BIXo1gEbDjR-wN0oi3hMQG1pbjVMCjxA520lL__SR0D0tWJdW9davqIHRKyQUlVF4SqsuCCEnPlD7XhFJViD20oqrSBeNa_ECrL8tPdJjzX0KIoLI8QAelpIxptUKbG9-2kCCM2Id3X_sxpg22bvQxZBxb7Pt-CrGPzdTZ0Yc3bN9mc8Y2NDstT8OQIGe_hv9iDLiOAfDcjmlYspaoPk4ZsLPd2iZvj9F-a7sMJ7t6hF7vbl-uH4qn5_vH6z9PheOCj4Wo6pKTltlKVCAsaxlI56AqVcO04Jo0omLSOlfWUgpZt4QwINAoR3lFFbAj9HubO6T4MUEeTe-zg66zAeaDDBVcciX0bORbo0sx5wStGZLvbdoYSsxC3Cw4zYLTKG0-iRsxj_3a5U91D83X0A7xrF9tdZifXHtIJjsPwUHjE7jRNNF_v-AfiOaS9Q</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Sasagawa, K</creator><creator>Fujibayashi, S</creator><creator>Okano, K</creator><creator>Nawa, C</creator><creator>Suzuki, S</creator><creator>Kou, S</creator><creator>Yamada, Y</creator><creator>Someya, K</creator><general>Elsevier Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>1989</creationdate><title>Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria</title><author>Sasagawa, K ; Fujibayashi, S ; Okano, K ; Nawa, C ; Suzuki, S ; Kou, S ; Yamada, Y ; Someya, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-57b240f3a757e5a3f3e6cce728d395490d5736acc2b6656bf003e0ed8c14718e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Bone Resorption - chemically induced</topic><topic>Bone Resorption - prevention & control</topic><topic>Chromones - pharmacology</topic><topic>Cyclosporins - pharmacology</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Interleukin-1 - pharmacology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>ortho-Aminobenzoates - pharmacology</topic><topic>Parathyroid Hormone - pharmacology</topic><topic>Ribonucleosides - pharmacology</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasagawa, K</creatorcontrib><creatorcontrib>Fujibayashi, S</creatorcontrib><creatorcontrib>Okano, K</creatorcontrib><creatorcontrib>Nawa, C</creatorcontrib><creatorcontrib>Suzuki, S</creatorcontrib><creatorcontrib>Kou, S</creatorcontrib><creatorcontrib>Yamada, Y</creatorcontrib><creatorcontrib>Someya, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasagawa, K</au><au>Fujibayashi, S</au><au>Okano, K</au><au>Nawa, C</au><au>Suzuki, S</au><au>Kou, S</au><au>Yamada, Y</au><au>Someya, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1989</date><risdate>1989</risdate><volume>11</volume><issue>8</issue><spage>953</spage><epage>959</epage><pages>953-959</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><abstract>In this study, we have investigated the
in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with
45Ca. As stimulators of bone resorption, bovine parathyroid hormone (PTH), lipopolysaccharide (LPS), interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) were used. Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1β or TNF-α in a dose-dependent manner. Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption. Removal of lobenzarit from the culture medium resulted in the recovery of bone resorptive activity. These results suggest that the inhibitory effect of immunomodulators on bone resorption is reversible and nonselective. Also, it raises the possibility that immunomodulators and immunosuppressants may affect bone resorption by different mechanisms.</abstract><cop>England</cop><pub>Elsevier Science</pub><pmid>2613398</pmid><doi>10.1016/0192-0561(89)90118-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of immunopharmacology, 1989, Vol.11 (8), p.953-959 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic - pharmacology Animals Bone Resorption - chemically induced Bone Resorption - prevention & control Chromones - pharmacology Cyclosporins - pharmacology Immunosuppressive Agents - pharmacology In Vitro Techniques Interleukin-1 - pharmacology Lipopolysaccharides - pharmacology Mice Mice, Inbred ICR ortho-Aminobenzoates - pharmacology Parathyroid Hormone - pharmacology Ribonucleosides - pharmacology Tumor Necrosis Factor-alpha - pharmacology |
| title | Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria |
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