Sexual behavior decreases pain sensitivity and stimulates endogenous opioids in male rats

Sexual behavior decreases pain sensitivity and stimulates endogenous opioids in male rats

In male rats copulation has antinociceptive effects as measured either by shock-induced vocalizations or hindlimb withdrawal to pinch. Prolonged mating reduces the content of endogenous opioids in midbrain but not in hypothamlamus or caudate nucleus. Blockage of opiate receptors with the narcotic an...

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Veröffentlicht in:European journal of pharmacology 1981-01, Vol.70 (3), p.279-285
Hauptverfasser: Szechtman, Henry, Hershkowitz, Moshe, Simantov, Rabi
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Sprache:eng
Schlagworte:
Analgesia
Midbrain
Naloxone
Reward
Sexual behavior
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container_title European journal of pharmacology
container_volume 70
creator Szechtman, Henry
Hershkowitz, Moshe
Simantov, Rabi
description In male rats copulation has antinociceptive effects as measured either by shock-induced vocalizations or hindlimb withdrawal to pinch. Prolonged mating reduces the content of endogenous opioids in midbrain but not in hypothamlamus or caudate nucleus. Blockage of opiate receptors with the narcotic antagonist naloxone (4 mg/kg) significantly extends the postejaculatory interval. The results indicate that mating is a biological stimulus for the release of endogenous opioids, possibly to (a) prevent intense sexual stimulation from becoming aversive, and (b) increase its reward value.
doi_str_mv 10.1016/0014-2999(81)90161-8
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source Elsevier ScienceDirect Journals Complete
subjects Analgesia
Midbrain
Naloxone
Reward
Sexual behavior
title Sexual behavior decreases pain sensitivity and stimulates endogenous opioids in male rats
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