A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products

Computational target prediction methods using chemical descriptors have been applied exhaustively in drug discovery to elucidate the mechanisms-of-action (MOAs) of small molecules. To predict truly novel and unexpected small molecule–target interactions, compounds must be compared by means other tha...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical biology 2014-07, Vol.9 (7), p.1622-1631
Hauptverfasser:	Wassermann, Anne Mai, Lounkine, Eugen, Urban, Laszlo, Whitebread, Steven, Chen, Shanni, Hughes, Kevin, Guo, Hongqiu, Kutlina, Elena, Fekete, Alexander, Klumpp, Martin, Glick, Meir
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemistry Biological Products - pharmacology Databases, Pharmaceutical Drug Discovery - methods Humans Models, Molecular Molecular Targeted Therapy Pharmaceutical Preparations - chemistry Pharmacology Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!