The Glucocorticoid Dexamethasone Inhibits U937 Cell Adhesion and Neutrophil Release via RhoA/ROCK1-Dependent and Independent Pathways

Aims: The aim of the present study was to investigate the role of the Ras homolog family member A (RhoA)/Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) signaling pathway in the inhibition of inflammatory responses by the glucocorticoid dexamethasone (Dex). Methods: The inhibitory eff...

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Veröffentlicht in:	Cellular physiology and biochemistry 2014-01, Vol.33 (6), p.1654-1662
Hauptverfasser:	Liu, Dong, Xiong, Renping, Chen, Xingyun, Li, Ping, Ning, Yalei, Peng, Yan, Zhao, Yan, Yang, Nan, Zhou, Yuanguo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Animals Cell Adhesion - drug effects Cells, Cultured Dexamethasone Dexamethasone - pharmacology Female Gene Expression - drug effects Glucocorticoids - pharmacology Humans Immunoblotting Male Neutrophils - drug effects Neutrophils - metabolism Non-genomic effects Original Paper Peroxidase - metabolism Protein Kinase Inhibitors - pharmacology Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction rho-Associated Kinases - genetics rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism ROCK1 Signal Transduction - drug effects Superoxides - metabolism Tetradecanoylphorbol Acetate - pharmacology U937 Cells
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