Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction

The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized functions. To investigate neuronal chromatin organization and dynamics in vivo , we generat...

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Veröffentlicht in:	Nature communications 2014-07, Vol.5 (1), p.4450-4450, Article 4450
Hauptverfasser:	Ito, Satomi, Magalska, Adriana, Alcaraz-Iborra, Manuel, Lopez-Atalaya, Jose P., Rovira, Victor, Contreras-Moreira, Bruno, Lipinski, Michal, Olivares, Roman, Martinez-Hernandez, Jose, Ruszczycki, Blazej, Lujan, Rafael, Geijo-Barrientos, Emilio, Wilczynski, Grzegorz M., Barco, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 13/51 14 14/28 14/32 38 38/15 38/35 38/39 38/77 42 59 631/208/2489/144 631/337/100/101 631/378/2584 64 64/60 692/699/476 Animals Behavior, Animal - physiology Cell Nucleus - genetics Cell Nucleus - metabolism Cell Nucleus - ultrastructure Chromatin - chemistry Chromatin - genetics Chromatin - ultrastructure Epigenesis, Genetic Euchromatin - metabolism Euchromatin - ultrastructure Gene Expression Regulation Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Heterochromatin - metabolism Histones - genetics Histones - metabolism Humanities and Social Sciences Mice, Inbred C57BL Mice, Transgenic multidisciplinary Neurons - metabolism Neurons - physiology Neurons - ultrastructure Prosencephalon - metabolism Prosencephalon - pathology Receptors, Serotonin - genetics Science Science (multidisciplinary) Serotonin - metabolism Transcription, Genetic
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