Nitric Oxide Prevents Aortic Neointimal Hyperplasia by Controlling Macrophage Polarization

OBJECTIVE—Nitric oxide synthase 3 (NOS3) prevents neointima hyperplasia by still unknown mechanisms. To demonstrate the significance of endothelial nitric oxide in the polarization of infiltrated macrophages through the expression of matrix metalloproteinase (MMP)-13 in neointima formation. APPROACH...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2014-08, Vol.34 (8), p.1739-1746
Hauptverfasser:	Lavin, Begoña, Gómez, Monica, Pello, Oscar M, Castejon, Borja, Piedras, Maria J, Saura, Marta, Zaragoza, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Aorta - metabolism Aorta - pathology Aortic Diseases - enzymology Aortic Diseases - genetics Aortic Diseases - metabolism Aortic Diseases - pathology Biomarkers - metabolism Case-Control Studies Cell Differentiation Cell Lineage Cell Movement Cell Proliferation Cells, Cultured Disease Models, Animal Female Humans Hyperplasia Inflammation Mediators - metabolism Macrophages - enzymology Macrophages - metabolism Macrophages - pathology Male Matrix Metalloproteinase 13 - deficiency Matrix Metalloproteinase 13 - genetics Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Neointima Nitric Oxide - metabolism Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - genetics Phenotype Proto-Oncogene Proteins c-myc - deficiency Proto-Oncogene Proteins c-myc - genetics Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!