A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability

Failure to expeditiously repair DNA at sites of double-strand breaks (DSB) ultimately is an important etiologic factor in cancer development. NBS1 plays an important role in the cellular response to DSB damage. A rare polymorphic variant of NBS1 that resulted in an isoleucine to valine substitution...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-07, Vol.74 (14), p.3707-3715
Hauptverfasser:	YAMAMOTO, Yuki, MIYAMOTO, Mamiko, TATSUDA, Daisuke, KUBO, Michiaki, NAKAGAMA, Hitoshi, NAKAMURA, Yusuke, SATOH, Hitoshi, MATSUDA, Koichi, WATANABE, Toshiki, OHTA, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Line, Tumor Chromosomal Instability DNA Breaks, Double-Stranded DNA Repair Female Humans Medical sciences Molecular Sequence Data Multiprotein Complexes - metabolism Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Pharmacology. Drug treatments Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Protein Binding Protein Transport Sequence Alignment Trans-Activators - metabolism Tumors
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