Multiple System Organ Response Induced by Hyperoxia in a Clinically Relevant Animal Model of Sepsis

ABSTRACTOxygen therapy is currently used as a supportive treatment in septic patients to improve tissue oxygenation. However, oxygen can exert deleterious effects on the inflammatory response triggered by infection. We postulated that the use of high oxygen concentrations may be partially responsibl...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2014-08, Vol.42 (2), p.148-153
Hauptverfasser:	Rodríguez-González, Raquel, Martín-Barrasa, José Luis, Ramos-Nuez, Ángela, Cañas-Pedrosa, Ana María, Martínez-Saavedra, María Teresa, García-Bello, Miguel Ángel, López-Aguilar, Josefina, Baluja, Aurora, Álvarez, Julián, Slutsky, Arthur S, Villar, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Disease Progression Hyperoxia - complications Hyperoxia - immunology Inflammation Mediators - metabolism Interleukin-10 - blood Interleukin-6 - blood Leukocyte Count Male Multiple Organ Failure - etiology Multiple Organ Failure - immunology Oxygen Inhalation Therapy - adverse effects Platelet Count Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Sepsis - complications Sepsis - immunology Sepsis - therapy Tumor Necrosis Factor-alpha - blood
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