Hematopoietic Precursor Cells in Mice Treated With 4-Demethoxydaunorubicin and Doxorubicin

The hematologic toxicity of 4-demethoxydaunorubicin (4-dmDNR), a new anthracycline more potent and less cardiotoxic than doxorubicin (Dx), was studied. Dose-survival curves of bone marrow hematopoietic precursor cells (HPC) in situ were determined with the use of (C57BL × C3H)F1 mice and with assays...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1982-06, Vol.68 (6), p.971-976
Hauptverfasser:	Massa, Giulio, Bogliolo, Giuseppe, D'Amore, Francesco, Muzzulini, Carlo, Ghio, Riccardo, Pannacciulli, Ivo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Colony-Forming Units Assay Daunorubicin - analogs & derivatives Daunorubicin - toxicity Dose-Response Relationship, Drug Doxorubicin - administration & dosage Drug Administration Schedule Erythrocytes - drug effects Hematopoietic Stem Cells - drug effects Idarubicin Mice Mice, Inbred C57BL Reticulocytes - drug effects Time Factors
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