Sirtuin 1 Activation Stimulates Mitochondrial Biogenesis and Attenuates Renal Injury After Ischemia-Reperfusion

BACKGROUNDRenal ischemia-reperfusion (I/R) is a major contributor to delayed graft function after renal transplantation. The pathophysiology of I/R can be summarized by a primary energy deficit during ischemia and a secondary phase of oxidative stress and inflammation. Sirtuin 1 is an energy-sensing...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 2014-07, Vol.98 (2), p.148-156
Hauptverfasser:	Khader, Adam, Yang, Weng-Lang, Kuncewitch, Michael, Jacob, Asha, Prince, Jose M, Asirvatham, Jaya R, Nicastro, Jeffrey, Coppa, Gene F, Wang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Disease Models, Animal Energy Metabolism - drug effects Enzyme Activation Enzyme Activators - pharmacology Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Inflammation Mediators - metabolism Kidney - drug effects Kidney - enzymology Kidney - pathology Kidney Diseases - enzymology Kidney Diseases - pathology Kidney Diseases - prevention & control Male Mitochondrial Turnover - drug effects Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Reperfusion Injury - enzymology Reperfusion Injury - pathology Reperfusion Injury - prevention & control Sirtuin 1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!